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Glioma and the gut–brain axis: opportunities and future perspectives

The gut–brain axis has presented a valuable new dynamic in the treatment of cancer and central nervous system (CNS) diseases. However, little is known about the potential role of this axis in neuro-oncology. The goal of this review is to highlight potential implications of the gut–brain axis in neur...

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Autores principales: Dono, Antonio, Nickles, Jack, Rodriguez-Armendariz, Ana G, McFarland, Braden C, Ajami, Nadim J, Ballester, Leomar Y, Wargo, Jennifer A, Esquenazi, Yoshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113089/
https://www.ncbi.nlm.nih.gov/pubmed/35591978
http://dx.doi.org/10.1093/noajnl/vdac054
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author Dono, Antonio
Nickles, Jack
Rodriguez-Armendariz, Ana G
McFarland, Braden C
Ajami, Nadim J
Ballester, Leomar Y
Wargo, Jennifer A
Esquenazi, Yoshua
author_facet Dono, Antonio
Nickles, Jack
Rodriguez-Armendariz, Ana G
McFarland, Braden C
Ajami, Nadim J
Ballester, Leomar Y
Wargo, Jennifer A
Esquenazi, Yoshua
author_sort Dono, Antonio
collection PubMed
description The gut–brain axis has presented a valuable new dynamic in the treatment of cancer and central nervous system (CNS) diseases. However, little is known about the potential role of this axis in neuro-oncology. The goal of this review is to highlight potential implications of the gut–brain axis in neuro-oncology, in particular gliomas, and future areas of research. The gut–brain axis is a well-established biochemical signaling axis that has been associated with various CNS diseases. In neuro-oncology, recent studies have described gut microbiome differences in tumor-bearing mice and glioma patients compared to controls. These differences in the composition of the microbiome are expected to impact the metabolic functionality of each microbiome. The effects of antibiotics on the microbiome may affect tumor growth and modulate the immune system in tumor-bearing mice. Preliminary studies have shown that the gut microbiome might influence PD-L1 response in glioma-bearing mice, as previously observed in other non-CNS cancers. Groundbreaking studies have identified intratumoral bacterial DNA in several cancers including high-grade glioma. The gut microbiome and its manipulation represent a new and relatively unexplored area that could be utilized to enhance the effectiveness of therapy in glioma. Further mechanistic studies of this therapeutic strategy are needed to assess its clinical relevance.
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spelling pubmed-91130892022-05-18 Glioma and the gut–brain axis: opportunities and future perspectives Dono, Antonio Nickles, Jack Rodriguez-Armendariz, Ana G McFarland, Braden C Ajami, Nadim J Ballester, Leomar Y Wargo, Jennifer A Esquenazi, Yoshua Neurooncol Adv Review The gut–brain axis has presented a valuable new dynamic in the treatment of cancer and central nervous system (CNS) diseases. However, little is known about the potential role of this axis in neuro-oncology. The goal of this review is to highlight potential implications of the gut–brain axis in neuro-oncology, in particular gliomas, and future areas of research. The gut–brain axis is a well-established biochemical signaling axis that has been associated with various CNS diseases. In neuro-oncology, recent studies have described gut microbiome differences in tumor-bearing mice and glioma patients compared to controls. These differences in the composition of the microbiome are expected to impact the metabolic functionality of each microbiome. The effects of antibiotics on the microbiome may affect tumor growth and modulate the immune system in tumor-bearing mice. Preliminary studies have shown that the gut microbiome might influence PD-L1 response in glioma-bearing mice, as previously observed in other non-CNS cancers. Groundbreaking studies have identified intratumoral bacterial DNA in several cancers including high-grade glioma. The gut microbiome and its manipulation represent a new and relatively unexplored area that could be utilized to enhance the effectiveness of therapy in glioma. Further mechanistic studies of this therapeutic strategy are needed to assess its clinical relevance. Oxford University Press 2022-04-14 /pmc/articles/PMC9113089/ /pubmed/35591978 http://dx.doi.org/10.1093/noajnl/vdac054 Text en © The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Dono, Antonio
Nickles, Jack
Rodriguez-Armendariz, Ana G
McFarland, Braden C
Ajami, Nadim J
Ballester, Leomar Y
Wargo, Jennifer A
Esquenazi, Yoshua
Glioma and the gut–brain axis: opportunities and future perspectives
title Glioma and the gut–brain axis: opportunities and future perspectives
title_full Glioma and the gut–brain axis: opportunities and future perspectives
title_fullStr Glioma and the gut–brain axis: opportunities and future perspectives
title_full_unstemmed Glioma and the gut–brain axis: opportunities and future perspectives
title_short Glioma and the gut–brain axis: opportunities and future perspectives
title_sort glioma and the gut–brain axis: opportunities and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113089/
https://www.ncbi.nlm.nih.gov/pubmed/35591978
http://dx.doi.org/10.1093/noajnl/vdac054
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