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Genome mining for drug discovery: cyclic lipopeptides related to daptomycin
The cyclic lipopeptide antibiotics structurally related to daptomycin were first reported in the 1950s. Several have common lipopeptide initiation, elongation, and termination mechanisms. Initiation requires the use of a fatty acyl-AMP ligase (FAAL), a free-standing acyl carrier protein (ACP), and a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113097/ https://www.ncbi.nlm.nih.gov/pubmed/33739403 http://dx.doi.org/10.1093/jimb/kuab020 |