Enhanced production of clavulanic acid by improving glycerol utilization using reporter-guided mutagenesis of an industrial Streptomyces clavuligerus strain

Clavulanic acid (CA) produced by Streptomyces clavuligerus is a clinically important β-lactamase inhibitor. It is known that glycerol utilization can significantly improve cell growth and CA production of S. clavuligerus. We found that the industrial CA-producing S. clavuligerus strain OR generated...

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Detalles Bibliográficos
Autores principales: Shin, Chang-Hun, Cho, Hang Su, Won, Hyung-Jin, Kwon, Ho Jeong, Kim, Chan-Wha, Yoon, Yeo Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Natural Products
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113135/
https://www.ncbi.nlm.nih.gov/pubmed/33693777
http://dx.doi.org/10.1093/jimb/kuab004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113135/
https://www.ncbi.nlm.nih.gov/pubmed/33693777
http://dx.doi.org/10.1093/jimb/kuab004

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