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Interferon regulatory factor-5-dependent CD11c(+) macrophages contribute to the formation of rupture–prone atherosclerotic plaques

AIMS: Inflammation is a key factor in atherosclerosis. The transcription factor interferon regulatory factor-5 (IRF5) drives macrophages towards a pro-inflammatory state. We investigated the role of IRF5 in human atherosclerosis and plaque stability. METHODS AND RESULTS: Bulk RNA sequencing from the...

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Detalles Bibliográficos
Autores principales:	Edsfeldt, Andreas, Swart, Maarten, Singh, Pratibha, Dib, Lea, Sun, Jiangming, Cole, Jennifer E, Park, Inhye, Al-Sharify, Dania, Persson, Ana, Nitulescu, Mihaela, Borges, Patricia Das Neves, Kassiteridi, Christina, Goddard, Michael E, Lee, Regent, Volkov, Petr, Orho-Melander, Marju, Maegdefessel, Lars, Nilsson, Jan, Udalova, Irina, Goncalves, Isabel, Monaco, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113304/ https://www.ncbi.nlm.nih.gov/pubmed/35567557 http://dx.doi.org/10.1093/eurheartj/ehab920

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