Primary hyperoxaluria: the pediatric nephrologist's point of view

The clinical presentation of primary hyperoxaluria in children ranges from mildly symptomatic nephrocalcinosis to very early onset end-stage kidney failure with systemic oxalosis, a devastating complication. We review the various manifestations of pediatric hyperoxaluria, treatment options for child...

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Detalles Bibliográficos
Autores principales: Ben-Shalom, Efrat, Garrelfs, Sander F, Groothoff, Jaap W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
CKJ Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113416/
https://www.ncbi.nlm.nih.gov/pubmed/35592624
http://dx.doi.org/10.1093/ckj/sfab231
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author Ben-Shalom, Efrat
Garrelfs, Sander F
Groothoff, Jaap W
author_facet Ben-Shalom, Efrat
Garrelfs, Sander F
Groothoff, Jaap W
author_sort Ben-Shalom, Efrat
collection PubMed
description The clinical presentation of primary hyperoxaluria in children ranges from mildly symptomatic nephrocalcinosis to very early onset end-stage kidney failure with systemic oxalosis, a devastating complication. We review the various manifestations of pediatric hyperoxaluria, treatment options for children with preserved kidney function and appropriate dialysis regimens. Liver or combined liver/kidney transplantation is currently the only definitive treatment for primary hyperoxaluria type 1, but novel RNA interference treatments offer hope for the future. Finally, we address the medical and ethical dilemmas facing pediatricians treating children with hyperoxaluria.
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spelling pubmed-91134162022-05-18 Primary hyperoxaluria: the pediatric nephrologist's point of view Ben-Shalom, Efrat Garrelfs, Sander F Groothoff, Jaap W Clin Kidney J CKJ Review The clinical presentation of primary hyperoxaluria in children ranges from mildly symptomatic nephrocalcinosis to very early onset end-stage kidney failure with systemic oxalosis, a devastating complication. We review the various manifestations of pediatric hyperoxaluria, treatment options for children with preserved kidney function and appropriate dialysis regimens. Liver or combined liver/kidney transplantation is currently the only definitive treatment for primary hyperoxaluria type 1, but novel RNA interference treatments offer hope for the future. Finally, we address the medical and ethical dilemmas facing pediatricians treating children with hyperoxaluria. Oxford University Press 2022-05-17 /pmc/articles/PMC9113416/ /pubmed/35592624 http://dx.doi.org/10.1093/ckj/sfab231 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle CKJ Review
Ben-Shalom, Efrat
Garrelfs, Sander F
Groothoff, Jaap W
Primary hyperoxaluria: the pediatric nephrologist's point of view
title Primary hyperoxaluria: the pediatric nephrologist's point of view
title_full Primary hyperoxaluria: the pediatric nephrologist's point of view
title_fullStr Primary hyperoxaluria: the pediatric nephrologist's point of view
title_full_unstemmed Primary hyperoxaluria: the pediatric nephrologist's point of view
title_short Primary hyperoxaluria: the pediatric nephrologist's point of view
title_sort primary hyperoxaluria: the pediatric nephrologist's point of view
topic CKJ Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113416/
https://www.ncbi.nlm.nih.gov/pubmed/35592624
http://dx.doi.org/10.1093/ckj/sfab231
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