Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia

Numerous studies have demonstrated the importance of the adaptive immunity for survival following Ebola virus (EBOV) infection. To evaluate the contribution of tissue damage to EBOV-induced immune suppression, acute liver damage or hemolysis, 2 symptoms associated with lethal EBOV infection, were ch...

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Autores principales: Fausther-Bovendo, Hugues, Qiu, Xiangguo, Babuadze, George Giorgi, Azizi, Hiva, Pedersen, Jannie, Wong, Gary, Kobinger, Gary P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113424/
https://www.ncbi.nlm.nih.gov/pubmed/34791300
http://dx.doi.org/10.1093/infdis/jiab552
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author Fausther-Bovendo, Hugues
Qiu, Xiangguo
Babuadze, George Giorgi
Azizi, Hiva
Pedersen, Jannie
Wong, Gary
Kobinger, Gary P
author_facet Fausther-Bovendo, Hugues
Qiu, Xiangguo
Babuadze, George Giorgi
Azizi, Hiva
Pedersen, Jannie
Wong, Gary
Kobinger, Gary P
author_sort Fausther-Bovendo, Hugues
collection PubMed
description Numerous studies have demonstrated the importance of the adaptive immunity for survival following Ebola virus (EBOV) infection. To evaluate the contribution of tissue damage to EBOV-induced immune suppression, acute liver damage or hemolysis, 2 symptoms associated with lethal EBOV infection, were chemically induced in vaccinated mice. Results show that either liver damage or hemolysis was sufficient to inhibit the host humoral response against EBOV glycoprotein and to drastically reduce the level of circulating T cells. This study thus provides a possible mechanism for the limited specific antibody production and lymphopenia in individuals with lethal hemorrhagic fever infections.
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spelling pubmed-91134242022-05-18 Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia Fausther-Bovendo, Hugues Qiu, Xiangguo Babuadze, George Giorgi Azizi, Hiva Pedersen, Jannie Wong, Gary Kobinger, Gary P J Infect Dis Major Articles and Brief Reports Numerous studies have demonstrated the importance of the adaptive immunity for survival following Ebola virus (EBOV) infection. To evaluate the contribution of tissue damage to EBOV-induced immune suppression, acute liver damage or hemolysis, 2 symptoms associated with lethal EBOV infection, were chemically induced in vaccinated mice. Results show that either liver damage or hemolysis was sufficient to inhibit the host humoral response against EBOV glycoprotein and to drastically reduce the level of circulating T cells. This study thus provides a possible mechanism for the limited specific antibody production and lymphopenia in individuals with lethal hemorrhagic fever infections. Oxford University Press 2021-11-17 /pmc/articles/PMC9113424/ /pubmed/34791300 http://dx.doi.org/10.1093/infdis/jiab552 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Fausther-Bovendo, Hugues
Qiu, Xiangguo
Babuadze, George Giorgi
Azizi, Hiva
Pedersen, Jannie
Wong, Gary
Kobinger, Gary P
Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia
title Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia
title_full Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia
title_fullStr Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia
title_full_unstemmed Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia
title_short Transient Liver Damage and Hemolysis Are Associated With an Inhibition of Ebola Virus Glycoprotein-Specific Antibody Response and Lymphopenia
title_sort transient liver damage and hemolysis are associated with an inhibition of ebola virus glycoprotein-specific antibody response and lymphopenia
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113424/
https://www.ncbi.nlm.nih.gov/pubmed/34791300
http://dx.doi.org/10.1093/infdis/jiab552
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