Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis

BACKGROUND: Limited evidence exists on efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis. METHODS: Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after 2 courses, during 2008–2020, were retro...

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Autores principales: Ydsten, Karin A, Hellgren, Urban, Asgeirsson, Hilmir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113433/
https://www.ncbi.nlm.nih.gov/pubmed/34036328
http://dx.doi.org/10.1093/infdis/jiab287
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author Ydsten, Karin A
Hellgren, Urban
Asgeirsson, Hilmir
author_facet Ydsten, Karin A
Hellgren, Urban
Asgeirsson, Hilmir
author_sort Ydsten, Karin A
collection PubMed
description BACKGROUND: Limited evidence exists on efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis. METHODS: Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after 2 courses, during 2008–2020, were retrospectively identified. RESULTS: Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and 3 combined with metronidazole. Only 3 had positive stool samples with persisting symptoms after quinacrine treatment (94% parasitological efficacy) and all were cured after a second treatment. One (1.9%) had mild adverse effects recorded. CONCLUSIONS: Quinacrine is an effective treatment for nitroimidazole-refractory giardiasis with good tolerability.
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spelling pubmed-91134332022-05-18 Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis Ydsten, Karin A Hellgren, Urban Asgeirsson, Hilmir J Infect Dis Major Articles and Brief Reports BACKGROUND: Limited evidence exists on efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis. METHODS: Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after 2 courses, during 2008–2020, were retrospectively identified. RESULTS: Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and 3 combined with metronidazole. Only 3 had positive stool samples with persisting symptoms after quinacrine treatment (94% parasitological efficacy) and all were cured after a second treatment. One (1.9%) had mild adverse effects recorded. CONCLUSIONS: Quinacrine is an effective treatment for nitroimidazole-refractory giardiasis with good tolerability. Oxford University Press 2021-05-24 /pmc/articles/PMC9113433/ /pubmed/34036328 http://dx.doi.org/10.1093/infdis/jiab287 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Ydsten, Karin A
Hellgren, Urban
Asgeirsson, Hilmir
Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis
title Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis
title_full Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis
title_fullStr Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis
title_full_unstemmed Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis
title_short Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis
title_sort quinacrine treatment of nitroimidazole-refractory giardiasis
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113433/
https://www.ncbi.nlm.nih.gov/pubmed/34036328
http://dx.doi.org/10.1093/infdis/jiab287
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