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Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity

Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of he...

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Autores principales: Han, Xin, Ding, Chuan, Ning, Yan, Shan, QiYuan, Niu, Minjie, Cai, Hao, Xu, Peng, Cao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113564/
https://www.ncbi.nlm.nih.gov/pubmed/35592634
http://dx.doi.org/10.3389/fnut.2022.807071
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author Han, Xin
Ding, Chuan
Ning, Yan
Shan, QiYuan
Niu, Minjie
Cai, Hao
Xu, Peng
Cao, Gang
author_facet Han, Xin
Ding, Chuan
Ning, Yan
Shan, QiYuan
Niu, Minjie
Cai, Hao
Xu, Peng
Cao, Gang
author_sort Han, Xin
collection PubMed
description Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of hepatic stellate cells-T6 (HSC-T6) and HK-2, our study used single-factor plus orthogonal design to investigate the anti-fibrosis of C. officinalis processed with steamed (S), high-pressure steamed (HPS), WS, high-pressure wine-steamed (HPWS), wine-dipped (WD), and wine-fried (WF). The chemical constituents in processed C. officinalis with higher anti-fibrotic activities were detected by ultra-high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Results showed that C. officinalis with HPWS significantly inhibited the activations of HSC-T6 and HK-2. Moreover, compounds in C. officinalis with HPWS were obtained via UHPLC-Q-TOF-MS/MS, indicating that 27 components were changed compared with raw C. officinalis. These results demonstrated that HPWS is the optimal processing technology for anti-fibrosis of C. officinalis.
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spelling pubmed-91135642022-05-18 Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity Han, Xin Ding, Chuan Ning, Yan Shan, QiYuan Niu, Minjie Cai, Hao Xu, Peng Cao, Gang Front Nutr Nutrition Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of hepatic stellate cells-T6 (HSC-T6) and HK-2, our study used single-factor plus orthogonal design to investigate the anti-fibrosis of C. officinalis processed with steamed (S), high-pressure steamed (HPS), WS, high-pressure wine-steamed (HPWS), wine-dipped (WD), and wine-fried (WF). The chemical constituents in processed C. officinalis with higher anti-fibrotic activities were detected by ultra-high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Results showed that C. officinalis with HPWS significantly inhibited the activations of HSC-T6 and HK-2. Moreover, compounds in C. officinalis with HPWS were obtained via UHPLC-Q-TOF-MS/MS, indicating that 27 components were changed compared with raw C. officinalis. These results demonstrated that HPWS is the optimal processing technology for anti-fibrosis of C. officinalis. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9113564/ /pubmed/35592634 http://dx.doi.org/10.3389/fnut.2022.807071 Text en Copyright © 2022 Han, Ding, Ning, Shan, Niu, Cai, Xu and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Han, Xin
Ding, Chuan
Ning, Yan
Shan, QiYuan
Niu, Minjie
Cai, Hao
Xu, Peng
Cao, Gang
Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity
title Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity
title_full Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity
title_fullStr Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity
title_full_unstemmed Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity
title_short Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity
title_sort optimizing processing technology of cornus officinalis: based on anti-fibrotic activity
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113564/
https://www.ncbi.nlm.nih.gov/pubmed/35592634
http://dx.doi.org/10.3389/fnut.2022.807071
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