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Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity
Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of he...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113564/ https://www.ncbi.nlm.nih.gov/pubmed/35592634 http://dx.doi.org/10.3389/fnut.2022.807071 |
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author | Han, Xin Ding, Chuan Ning, Yan Shan, QiYuan Niu, Minjie Cai, Hao Xu, Peng Cao, Gang |
author_facet | Han, Xin Ding, Chuan Ning, Yan Shan, QiYuan Niu, Minjie Cai, Hao Xu, Peng Cao, Gang |
author_sort | Han, Xin |
collection | PubMed |
description | Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of hepatic stellate cells-T6 (HSC-T6) and HK-2, our study used single-factor plus orthogonal design to investigate the anti-fibrosis of C. officinalis processed with steamed (S), high-pressure steamed (HPS), WS, high-pressure wine-steamed (HPWS), wine-dipped (WD), and wine-fried (WF). The chemical constituents in processed C. officinalis with higher anti-fibrotic activities were detected by ultra-high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Results showed that C. officinalis with HPWS significantly inhibited the activations of HSC-T6 and HK-2. Moreover, compounds in C. officinalis with HPWS were obtained via UHPLC-Q-TOF-MS/MS, indicating that 27 components were changed compared with raw C. officinalis. These results demonstrated that HPWS is the optimal processing technology for anti-fibrosis of C. officinalis. |
format | Online Article Text |
id | pubmed-9113564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91135642022-05-18 Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity Han, Xin Ding, Chuan Ning, Yan Shan, QiYuan Niu, Minjie Cai, Hao Xu, Peng Cao, Gang Front Nutr Nutrition Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of hepatic stellate cells-T6 (HSC-T6) and HK-2, our study used single-factor plus orthogonal design to investigate the anti-fibrosis of C. officinalis processed with steamed (S), high-pressure steamed (HPS), WS, high-pressure wine-steamed (HPWS), wine-dipped (WD), and wine-fried (WF). The chemical constituents in processed C. officinalis with higher anti-fibrotic activities were detected by ultra-high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Results showed that C. officinalis with HPWS significantly inhibited the activations of HSC-T6 and HK-2. Moreover, compounds in C. officinalis with HPWS were obtained via UHPLC-Q-TOF-MS/MS, indicating that 27 components were changed compared with raw C. officinalis. These results demonstrated that HPWS is the optimal processing technology for anti-fibrosis of C. officinalis. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9113564/ /pubmed/35592634 http://dx.doi.org/10.3389/fnut.2022.807071 Text en Copyright © 2022 Han, Ding, Ning, Shan, Niu, Cai, Xu and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Han, Xin Ding, Chuan Ning, Yan Shan, QiYuan Niu, Minjie Cai, Hao Xu, Peng Cao, Gang Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
title | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
title_full | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
title_fullStr | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
title_full_unstemmed | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
title_short | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
title_sort | optimizing processing technology of cornus officinalis: based on anti-fibrotic activity |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113564/ https://www.ncbi.nlm.nih.gov/pubmed/35592634 http://dx.doi.org/10.3389/fnut.2022.807071 |
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