Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function. We developed C17, a potent small-molecule DYRK2 inhibitor, through multiple rounds of struct...

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Detalles Bibliográficos
Autores principales: Wei, Tiantian, Wang, Jue, Liang, Ruqi, Chen, Wendong, Chen, Yilan, Ma, Mingzhe, He, An, Du, Yifei, Zhou, Wenjing, Zhang, Zhiying, Zeng, Xin, Wang, Chu, Lu, Jin, Guo, Xing, Chen, Xiao-Wei, Wang, Youjun, Tian, Ruijun, Xiao, Junyu, Lei, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113749/
https://www.ncbi.nlm.nih.gov/pubmed/35439114
http://dx.doi.org/10.7554/eLife.77696

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