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Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma

Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small-cell lung cancer (NSCLC). Here, we present information on the clinicopathologic characteristics and clinical outcomes of this type of cancer. Clinicopathologic data from 55 patients treated at a single cancer center...

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Autores principales: Sun, Jiachun, Jiang, Zhiyi, Shan, Tanyou, Yang, Ruina, Kong, Dejiu, Rui, Junshuai, Li, Xinyang, Kong, Guoqiang, Chang, Baoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113756/
https://www.ncbi.nlm.nih.gov/pubmed/35592676
http://dx.doi.org/10.3389/fonc.2022.833486
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author Sun, Jiachun
Jiang, Zhiyi
Shan, Tanyou
Yang, Ruina
Kong, Dejiu
Rui, Junshuai
Li, Xinyang
Kong, Guoqiang
Chang, Baoping
author_facet Sun, Jiachun
Jiang, Zhiyi
Shan, Tanyou
Yang, Ruina
Kong, Dejiu
Rui, Junshuai
Li, Xinyang
Kong, Guoqiang
Chang, Baoping
author_sort Sun, Jiachun
collection PubMed
description Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small-cell lung cancer (NSCLC). Here, we present information on the clinicopathologic characteristics and clinical outcomes of this type of cancer. Clinicopathologic data from 55 patients treated at a single cancer center from January 2011 to December 2018 were retrospectively analyzed. The patients were mostly male (76.4%), with a median age of 66 years and a history of smoking (54.5%). Most had symptoms, and about 60% presented with locally advanced or metastatic disease at diagnosis. Of the 55 cases, 21 were diagnosed by surgical resection. Pleomorphic cancer was the most common subtype (58.1%). With a median follow-up period of 13.2 months, the average survival time of the patients was 16.1 months, and the median survival time was 12 months. The overall survival rates for 1, 2, and 3 years were 52.7%, 18.2%, and 9.1%, respectively. Univariate analysis showed that prognosis of the patients was influenced by tumor size, T stage, metastatic status, and surgery (p < 0.05). Multivariate analysis showed that T stage (p = 0.034) was an independent prognostic factor. There are few reports on the natural history of PSC, and its clinicopathological characteristics remain unclear. Herein, a retrospective review 55 individuals with PSC found that T stage was an independent predictor of survival. Surgical resection was associated with better prognosis.
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spelling pubmed-91137562022-05-18 Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma Sun, Jiachun Jiang, Zhiyi Shan, Tanyou Yang, Ruina Kong, Dejiu Rui, Junshuai Li, Xinyang Kong, Guoqiang Chang, Baoping Front Oncol Oncology Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small-cell lung cancer (NSCLC). Here, we present information on the clinicopathologic characteristics and clinical outcomes of this type of cancer. Clinicopathologic data from 55 patients treated at a single cancer center from January 2011 to December 2018 were retrospectively analyzed. The patients were mostly male (76.4%), with a median age of 66 years and a history of smoking (54.5%). Most had symptoms, and about 60% presented with locally advanced or metastatic disease at diagnosis. Of the 55 cases, 21 were diagnosed by surgical resection. Pleomorphic cancer was the most common subtype (58.1%). With a median follow-up period of 13.2 months, the average survival time of the patients was 16.1 months, and the median survival time was 12 months. The overall survival rates for 1, 2, and 3 years were 52.7%, 18.2%, and 9.1%, respectively. Univariate analysis showed that prognosis of the patients was influenced by tumor size, T stage, metastatic status, and surgery (p < 0.05). Multivariate analysis showed that T stage (p = 0.034) was an independent prognostic factor. There are few reports on the natural history of PSC, and its clinicopathological characteristics remain unclear. Herein, a retrospective review 55 individuals with PSC found that T stage was an independent predictor of survival. Surgical resection was associated with better prognosis. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9113756/ /pubmed/35592676 http://dx.doi.org/10.3389/fonc.2022.833486 Text en Copyright © 2022 Sun, Jiang, Shan, Yang, Kong, Rui, Li, Kong and Chang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Sun, Jiachun
Jiang, Zhiyi
Shan, Tanyou
Yang, Ruina
Kong, Dejiu
Rui, Junshuai
Li, Xinyang
Kong, Guoqiang
Chang, Baoping
Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma
title Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma
title_full Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma
title_fullStr Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma
title_full_unstemmed Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma
title_short Characteristics and Prognostic Analysis of 55 Patients With Pulmonary Sarcomatoid Carcinoma
title_sort characteristics and prognostic analysis of 55 patients with pulmonary sarcomatoid carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113756/
https://www.ncbi.nlm.nih.gov/pubmed/35592676
http://dx.doi.org/10.3389/fonc.2022.833486
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