Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities

CONTEXT: Genetic variants affecting the nuclear hormone receptor coactivator steroid receptor coactivator, SRC-1, have been identified in people with severe obesity and impair melanocortin signaling in cells and mice. As a result, obese patients with SRC-1 deficiency are being treated with a melanoc...

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Detalles Bibliográficos
Autores principales: Cacciottolo, Tessa M, Henning, Elana, Keogh, Julia M, Bel Lassen, Pierre, Lawler, Katherine, Bounds, Rebecca, Ahmed, Rachel, Perdikari, Aliki, Mendes de Oliveira, Edson, Smith, Miriam, Godfrey, Edmund M, Johnson, Elspeth, Hodson, Leanne, Clément, Karine, van der Klaauw, Agatha A, Farooqi, I Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Online Only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113786/
https://www.ncbi.nlm.nih.gov/pubmed/35137184
http://dx.doi.org/10.1210/clinem/dgac067

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