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A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis

OBJECTIVE: This study aims to evaluate the efficacy of various conventional synthetic DMARDs, including Tripterygium wilfordii Hook F (TwHF) for treating rheumatoid arthritis (RA) by network meta-analysis. METHODS: We retrieved the related literature from online databases and supplemented it by usin...

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Autores principales: Wang, Hai-long, Zhao, Qi, Li, Wei, Zhu, Hua-chao, Lv, Liu, Zhu, Zhen-hong, Wang, Xi-xi, Yang, Zheng-zheng, Ma, Yu-cao, Liu, Ming-xuan, Wang, Yi-wen, Lai, Hezheng, Liu, Chun-ping, Yang, Yu-zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113883/
https://www.ncbi.nlm.nih.gov/pubmed/35591865
http://dx.doi.org/10.1155/2022/3181427
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author Wang, Hai-long
Zhao, Qi
Li, Wei
Zhu, Hua-chao
Lv, Liu
Zhu, Zhen-hong
Wang, Xi-xi
Yang, Zheng-zheng
Ma, Yu-cao
Liu, Ming-xuan
Wang, Yi-wen
Lai, Hezheng
Liu, Chun-ping
Yang, Yu-zheng
author_facet Wang, Hai-long
Zhao, Qi
Li, Wei
Zhu, Hua-chao
Lv, Liu
Zhu, Zhen-hong
Wang, Xi-xi
Yang, Zheng-zheng
Ma, Yu-cao
Liu, Ming-xuan
Wang, Yi-wen
Lai, Hezheng
Liu, Chun-ping
Yang, Yu-zheng
author_sort Wang, Hai-long
collection PubMed
description OBJECTIVE: This study aims to evaluate the efficacy of various conventional synthetic DMARDs, including Tripterygium wilfordii Hook F (TwHF) for treating rheumatoid arthritis (RA) by network meta-analysis. METHODS: We retrieved the related literature from online databases and supplemented it by using a manual retrieval method. Data was extracted from the literature and analyzed with STATA software. RESULTS: A total of 21 trials (5,039 participants) were identified. Assessment of ACR20 response found that TwHF combined with methotrexate (MTX) had the greatest probability for being the best treatment option among the treatments involved, while TwHF used singly was second only to TwHF combined with MTX. Assessment of ACR50 response found that TwHF combined with MTX ranked second in all treatment options after cyclosporine A (CsA) combined with leflunomide (LEF) and TwHF alone, followed by TwHF combined with MTX. Assessment of ACR70 response found that CsA combined with LEF ranked first, TwHF combined with LEF ranked second, TwHF combined with MTX ranked third, and TwHF used singly ranked fourth. In the safety analysis, TwHF had the least probability of adverse event occurrence, followed by TwHF combined with MTX, which ranked first and second, respectively. CONCLUSION: Compared with the current csDMARDs for treating RA, the efficacy of TwHF was clear, and TwHF combined with MTX performed well under various endpoints. In the future, large, rigorous, and high-quality RCTs are still needed to confirm the benefits of TwHF therapy on RA.
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spelling pubmed-91138832022-05-18 A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis Wang, Hai-long Zhao, Qi Li, Wei Zhu, Hua-chao Lv, Liu Zhu, Zhen-hong Wang, Xi-xi Yang, Zheng-zheng Ma, Yu-cao Liu, Ming-xuan Wang, Yi-wen Lai, Hezheng Liu, Chun-ping Yang, Yu-zheng Evid Based Complement Alternat Med Review Article OBJECTIVE: This study aims to evaluate the efficacy of various conventional synthetic DMARDs, including Tripterygium wilfordii Hook F (TwHF) for treating rheumatoid arthritis (RA) by network meta-analysis. METHODS: We retrieved the related literature from online databases and supplemented it by using a manual retrieval method. Data was extracted from the literature and analyzed with STATA software. RESULTS: A total of 21 trials (5,039 participants) were identified. Assessment of ACR20 response found that TwHF combined with methotrexate (MTX) had the greatest probability for being the best treatment option among the treatments involved, while TwHF used singly was second only to TwHF combined with MTX. Assessment of ACR50 response found that TwHF combined with MTX ranked second in all treatment options after cyclosporine A (CsA) combined with leflunomide (LEF) and TwHF alone, followed by TwHF combined with MTX. Assessment of ACR70 response found that CsA combined with LEF ranked first, TwHF combined with LEF ranked second, TwHF combined with MTX ranked third, and TwHF used singly ranked fourth. In the safety analysis, TwHF had the least probability of adverse event occurrence, followed by TwHF combined with MTX, which ranked first and second, respectively. CONCLUSION: Compared with the current csDMARDs for treating RA, the efficacy of TwHF was clear, and TwHF combined with MTX performed well under various endpoints. In the future, large, rigorous, and high-quality RCTs are still needed to confirm the benefits of TwHF therapy on RA. Hindawi 2022-05-10 /pmc/articles/PMC9113883/ /pubmed/35591865 http://dx.doi.org/10.1155/2022/3181427 Text en Copyright © 2022 Hai-long Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Hai-long
Zhao, Qi
Li, Wei
Zhu, Hua-chao
Lv, Liu
Zhu, Zhen-hong
Wang, Xi-xi
Yang, Zheng-zheng
Ma, Yu-cao
Liu, Ming-xuan
Wang, Yi-wen
Lai, Hezheng
Liu, Chun-ping
Yang, Yu-zheng
A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis
title A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis
title_full A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis
title_fullStr A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis
title_full_unstemmed A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis
title_short A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis
title_sort systematic review and network meta-analysis about the efficacy and safety of tripterygium wilfordii hook f in rheumatoid arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113883/
https://www.ncbi.nlm.nih.gov/pubmed/35591865
http://dx.doi.org/10.1155/2022/3181427
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