Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells

Mutational activation of the KRAS gene occurs in almost all pancreatic ductal adenocarcinoma (PDAC) and is the earliest molecular event in their carcinogenesis. Evidence has accumulated of the metabolic reprogramming in PDAC, such as amino acid homeostasis and autophagic flux. However, the biologica...

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Detalles Bibliográficos
Autores principales: Suzuki, Tatsunori, Kishikawa, Takahiro, Sato, Tatsuyuki, Takeda, Norihiko, Sugiura, Yuki, Seimiya, Takahiro, Sekiba, Kazuma, Ohno, Motoko, Iwata, Takuma, Ishibashi, Rei, Otsuka, Motoyuki, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113932/
https://www.ncbi.nlm.nih.gov/pubmed/33833413
http://dx.doi.org/10.1038/s41417-021-00326-4

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