Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts

Overexpression of O(6)-methylguanine DNA methyltransferase (MGMT) contributes to resistance to chemo-radiation therapy (CRT) in brain tumors. We previously demonstrated that non-ablative radiation improved delivery of anti-MGMT morpholino oligonucleotides (AMONs) to reduce MGMT levels in subcutaneou...

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Detalles Bibliográficos
Autores principales: Ambady, Prakash, Wu, Yingjen Jeffrey, Kersch, Cymon N., Walker, Joshua M., Holland, Samantha, Muldoon, Leslie L., Neuwelt, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113935/
https://www.ncbi.nlm.nih.gov/pubmed/33850305
http://dx.doi.org/10.1038/s41417-021-00324-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113935/
https://www.ncbi.nlm.nih.gov/pubmed/33850305
http://dx.doi.org/10.1038/s41417-021-00324-6

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