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The ERG1 K(+) Channel and Its Role in Neuronal Health and Disease

The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated w...

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Autores principales: Sanchez-Conde, Francisco G., Jimenez-Vazquez, Eric N., Auerbach, David S., Jones, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113952/
https://www.ncbi.nlm.nih.gov/pubmed/35600076
http://dx.doi.org/10.3389/fnmol.2022.890368
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author Sanchez-Conde, Francisco G.
Jimenez-Vazquez, Eric N.
Auerbach, David S.
Jones, David K.
author_facet Sanchez-Conde, Francisco G.
Jimenez-Vazquez, Eric N.
Auerbach, David S.
Jones, David K.
author_sort Sanchez-Conde, Francisco G.
collection PubMed
description The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1’s relationship to the mammalian brain and highlights key questions that have yet to be answered.
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spelling pubmed-91139522022-05-19 The ERG1 K(+) Channel and Its Role in Neuronal Health and Disease Sanchez-Conde, Francisco G. Jimenez-Vazquez, Eric N. Auerbach, David S. Jones, David K. Front Mol Neurosci Neuroscience The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1’s relationship to the mammalian brain and highlights key questions that have yet to be answered. Frontiers Media S.A. 2022-05-03 /pmc/articles/PMC9113952/ /pubmed/35600076 http://dx.doi.org/10.3389/fnmol.2022.890368 Text en Copyright © 2022 Sanchez-Conde, Jimenez-Vazquez, Auerbach and Jones. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sanchez-Conde, Francisco G.
Jimenez-Vazquez, Eric N.
Auerbach, David S.
Jones, David K.
The ERG1 K(+) Channel and Its Role in Neuronal Health and Disease
title The ERG1 K(+) Channel and Its Role in Neuronal Health and Disease
title_full The ERG1 K(+) Channel and Its Role in Neuronal Health and Disease
title_fullStr The ERG1 K(+) Channel and Its Role in Neuronal Health and Disease
title_full_unstemmed The ERG1 K(+) Channel and Its Role in Neuronal Health and Disease
title_short The ERG1 K(+) Channel and Its Role in Neuronal Health and Disease
title_sort erg1 k(+) channel and its role in neuronal health and disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113952/
https://www.ncbi.nlm.nih.gov/pubmed/35600076
http://dx.doi.org/10.3389/fnmol.2022.890368
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