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BMPR-IB gene disruption causes severe limb deformities in pigs

In an attempt to generate g.A746G substitution in the BMPR-IB gene, we unexpectedly obtained BMPR-IB homozygous knockout piglets (BMPR-IB(-/-)) and heterogeneous knockout piglets with one copy of the A746G mutation (BMPR-IB(-/746G)) via CRISPR/Cas9 editing. Polymerase chain reaction (PCR) and sequen...

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Detalles Bibliográficos
Autores principales:	Yang, Qiang, Qiao, Chuan-Min, Liu, Wei-Wei, Jiang, Hao-Yun, Jing, Qi-Qi, Liao, Ya-Ya, Ren, Jun, Xing, Yu-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Science Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113981/ https://www.ncbi.nlm.nih.gov/pubmed/35362676 http://dx.doi.org/10.24272/j.issn.2095-8137.2021.291

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