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Deep learning modeling m(6)A deposition reveals the importance of downstream cis-element sequences
The N(6)-methyladenosine (m(6)A) modification is deposited to nascent transcripts on chromatin, but its site-specificity mechanism is mostly unknown. Here we model the m(6)A deposition to pre-mRNA by iM6A (intelligent m(6)A), a deep learning method, demonstrating that the site-specific m(6)A methyla...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114009/ https://www.ncbi.nlm.nih.gov/pubmed/35581216 http://dx.doi.org/10.1038/s41467-022-30209-7 |