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N-type fast inactivation of a eukaryotic voltage-gated sodium channel

Voltage-gated sodium (Na(V)) channels initiate action potentials. Fast inactivation of Na(V) channels, mediated by an Ile-Phe-Met motif, is crucial for preventing hyperexcitability and regulating firing frequency. Here we present cryo-electron microscopy structure of Na(V)Eh from the coccolithophore...

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Detalles Bibliográficos
Autores principales:	Zhang, Jiangtao, Shi, Yiqiang, Fan, Junping, Chen, Huiwen, Xia, Zhanyi, Huang, Bo, Jiang, Juquan, Gong, Jianke, Huang, Zhuo, Jiang, Daohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114117/ https://www.ncbi.nlm.nih.gov/pubmed/35581266 http://dx.doi.org/10.1038/s41467-022-30400-w

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