CRISPR-based VEGF suppression using paired guide RNAs for treatment of choroidal neovascularization

Clustered regularly interspaced short palindromic repeats (CRISPR)-based genomic disruption of vascular endothelial growth factor A (Vegfa) with a single gRNA suppresses choroidal neovascularization (CNV) in preclinical studies, offering the prospect of long-term anti-angiogenesis therapy for neovas...

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Detalles Bibliográficos
Autores principales: Chung, Sook Hyun, Sin, Tzu-Ni, Dang, Brian, Ngo, Taylor, Lo, Therlinder, Lent-Schochet, Daniella, Meleppat, Ratheesh K., Zawadzki, Robert J., Yiu, Glenn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114159/
https://www.ncbi.nlm.nih.gov/pubmed/35614998
http://dx.doi.org/10.1016/j.omtn.2022.04.015

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