Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS

Fused in Sarcoma (FUS) is a nuclear RNA/DNA binding protein that mislocalizes to the cytoplasm in the neurodegenerative diseases ALS and FTD. Despite the existence of FUS pathogenic mutations that result in nuclear import defects, a subset of ALS/FTD patients display cytoplasmic accumulation of wild...

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Detalles Bibliográficos
Autores principales: Tsai, Yueh-Lin, Mu, Yu Chun, Manley, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114323/
https://www.ncbi.nlm.nih.gov/pubmed/35581240
http://dx.doi.org/10.1038/s41598-022-12098-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114323/
https://www.ncbi.nlm.nih.gov/pubmed/35581240
http://dx.doi.org/10.1038/s41598-022-12098-4

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