Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure or effective treatment in which TAR DNA Binding Protein of 43 kDa (TDP-43) abnormally accumulates into misfolded protein aggregates in affected neurons. It is widely accepted that protein misfolding and aggregation...

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Detalles Bibliográficos
Autores principales: François-Moutal, Liberty, Scott, David Donald, Ambrose, Andrew J., Zerio, Christopher J., Rodriguez-Sanchez, Marina, Dissanayake, Kumara, May, Danielle G., Carlson, Jacob M., Barbieri, Edward, Moutal, Aubin, Roux, Kyle J., Shorter, James, Khanna, Rajesh, Barmada, Sami J., McGurk, Leeanne, Khanna, May
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114370/
https://www.ncbi.nlm.nih.gov/pubmed/35581326
http://dx.doi.org/10.1038/s41598-022-12191-8

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