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Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms

Multi-UTR genes are widely transcribed and express their alternative 3′UTR isoforms in a cell type-specific manner. As transcriptional enhancers regulate mRNA expression, we investigated if they also regulate 3′UTR isoform expression. Endogenous enhancer deletion of the multi-UTR gene PTEN did not i...

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Detalles Bibliográficos
Autores principales:	Kwon, Buki, Fansler, Mervin M., Patel, Neil D., Lee, Jihye, Ma, Weirui, Mayr, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114392/ https://www.ncbi.nlm.nih.gov/pubmed/35581194 http://dx.doi.org/10.1038/s41467-022-30525-y

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