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Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study

Effective cancer treatment is currently the number one challenge to human health. To date, several treatment methods have been introduced for cancer cell targeting. Among the proposed new methods for attacking cancer cells, nanotechnology has attracted much attention. Hence, various nanocarriers hav...

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Detalles Bibliográficos
Autores principales: Rostami, Neda, Davarnejad, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114444/
https://www.ncbi.nlm.nih.gov/pubmed/34812575
http://dx.doi.org/10.1049/nbt2.12073
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author Rostami, Neda
Davarnejad, Reza
author_facet Rostami, Neda
Davarnejad, Reza
author_sort Rostami, Neda
collection PubMed
description Effective cancer treatment is currently the number one challenge to human health. To date, several treatment methods have been introduced for cancer cell targeting. Among the proposed new methods for attacking cancer cells, nanotechnology has attracted much attention. Hence, various nanocarriers have been developed for targeted delivery of available drugs and improve their effectiveness against malignant cells. The PLA–PEG functionalised with folic acid (PLA–PEG‐FA) is one of the nanocarriers with a limited range of applications for targeting cancer cells. In this investigation, different types of in‐silico methods such as molecular docking approach, molecular dynamics simulation and free energy calculations are employed to characterise the carriers studied. The effectiveness of PLA–PEG‐FA and PLA–PEG in delivering Letrozole as an aromatase inhibitor in cancer cells is examined. It is found that in the presence of folic acid, the stability and cell membrane permeability of nanomicelle are increased. Therefore, PLA–PEG‐FA can be considered as a versatile carrier that can increase the effectiveness of aromatase inhibitors (such as Letrozole) and reduce their side effects.
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spelling pubmed-91144442022-05-20 Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study Rostami, Neda Davarnejad, Reza IET Nanobiotechnol Micromechanics in Biology and Medicine Effective cancer treatment is currently the number one challenge to human health. To date, several treatment methods have been introduced for cancer cell targeting. Among the proposed new methods for attacking cancer cells, nanotechnology has attracted much attention. Hence, various nanocarriers have been developed for targeted delivery of available drugs and improve their effectiveness against malignant cells. The PLA–PEG functionalised with folic acid (PLA–PEG‐FA) is one of the nanocarriers with a limited range of applications for targeting cancer cells. In this investigation, different types of in‐silico methods such as molecular docking approach, molecular dynamics simulation and free energy calculations are employed to characterise the carriers studied. The effectiveness of PLA–PEG‐FA and PLA–PEG in delivering Letrozole as an aromatase inhibitor in cancer cells is examined. It is found that in the presence of folic acid, the stability and cell membrane permeability of nanomicelle are increased. Therefore, PLA–PEG‐FA can be considered as a versatile carrier that can increase the effectiveness of aromatase inhibitors (such as Letrozole) and reduce their side effects. John Wiley and Sons Inc. 2021-11-23 /pmc/articles/PMC9114444/ /pubmed/34812575 http://dx.doi.org/10.1049/nbt2.12073 Text en © 2021 Arak University. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Micromechanics in Biology and Medicine
Rostami, Neda
Davarnejad, Reza
Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study
title Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study
title_full Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study
title_fullStr Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study
title_full_unstemmed Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study
title_short Characterization of folic acid‐functionalized PLA–PEG nanomicelle to deliver Letrozole: A nanoinformatics study
title_sort characterization of folic acid‐functionalized pla–peg nanomicelle to deliver letrozole: a nanoinformatics study
topic Micromechanics in Biology and Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114444/
https://www.ncbi.nlm.nih.gov/pubmed/34812575
http://dx.doi.org/10.1049/nbt2.12073
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