Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity

The SARS-CoV-2 pandemic and particularly the emerging variants have deepened the need for widely available therapeutic options. We have demonstrated that hexamer-enhancing mutations in the Fc region of anti-SARS-CoV IgG antibodies lead to a noticeable improvement in IC(50) in both pseudo and live vi...

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Detalles Bibliográficos
Autores principales: Pande, Kalyan, Hollingsworth, Scott A., Sam, Miranda, Gao, Qinshan, Singh, Sujata, Saha, Anasuya, Vroom, Karin, Ma, Xiaohong Shirley, Brazell, Tres, Gorman, Dan, Chen, Shi-Juan, Raoufi, Fahimeh, Bailly, Marc, Grandy, David, Sathiyamoorthy, Karthik, Zhang, Lan, Thompson, Rob, Cheng, Alan C., Fayadat-Dilman, Laurence, Geierstanger, Bernhard H., Kingsley, Laura J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114490/
https://www.ncbi.nlm.nih.gov/pubmed/35603164
http://dx.doi.org/10.3389/fimmu.2022.864775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114490/
https://www.ncbi.nlm.nih.gov/pubmed/35603164
http://dx.doi.org/10.3389/fimmu.2022.864775

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