JAM-A signals through the Hippo pathway to regulate intestinal epithelial proliferation

JAM-A is a tight-junction-associated protein that contributes to regulation of intestinal homeostasis. We report that JAM-A interacts with NF2 and LATS1, functioning as an initiator of the Hippo signaling pathway, well-known for regulation of proliferation. Consistent with these findings, we observe...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, Shuling, Smith, Michelle Sydney, Keeney, Justin, O’Leary, Monique N., Nusrat, Asma, Parkos, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114518/
https://www.ncbi.nlm.nih.gov/pubmed/35602956
http://dx.doi.org/10.1016/j.isci.2022.104316

Ejemplares similares

Ejemplares similares