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Secondary developmental glaucoma in eyes with congenital aphakia

PURPOSE: To describe the clinical spectrum and management of glaucoma in congenital aphakia. METHODS: The demographics and clinical spectrum of eyes with congenital aphakia with and without glaucoma were compared, and management outcomes of congenital aphakia cases with glaucoma were studied retrosp...

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Autores principales: Badakere, Swathi Vallabh, Aulakh, Simranjeet, Achanta, Divya Sree Ramya, Chary, Raghava, Senthil, Sirisha, Chaurasia, Sunita, Ramappa, Muralidhar, Edward, Deepak P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114612/
https://www.ncbi.nlm.nih.gov/pubmed/35225525
http://dx.doi.org/10.4103/ijo.IJO_1782_21
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author Badakere, Swathi Vallabh
Aulakh, Simranjeet
Achanta, Divya Sree Ramya
Chary, Raghava
Senthil, Sirisha
Chaurasia, Sunita
Ramappa, Muralidhar
Edward, Deepak P
author_facet Badakere, Swathi Vallabh
Aulakh, Simranjeet
Achanta, Divya Sree Ramya
Chary, Raghava
Senthil, Sirisha
Chaurasia, Sunita
Ramappa, Muralidhar
Edward, Deepak P
author_sort Badakere, Swathi Vallabh
collection PubMed
description PURPOSE: To describe the clinical spectrum and management of glaucoma in congenital aphakia. METHODS: The demographics and clinical spectrum of eyes with congenital aphakia with and without glaucoma were compared, and management outcomes of congenital aphakia cases with glaucoma were studied retrospectively between April 2000 and June 2020. RESULTS: There were a total of 168 eyes (84 subjects) with a diagnosis of congenital aphakia, of which 29 eyes of 18 subjects were diagnosed with glaucoma. Corneal opacity was the presenting complaint in 26/29 eyes with glaucoma and 139/139 eyes without glaucoma. The (interquartile range (IQR)) horizontal corneal diameter was 10.5mm (IQR, 9.0-12.5) and 8mm (IQR, 5-10) in eyes with and without glaucoma (P = 0.01), respectively. The median (IQR) axial length was 17.5mm (IQR, 13.5-19.5) and 15mm (IQR, 14-16) mm in eyes with and without glaucoma (P = 0.03), respectively. Nineteen eyes with glaucoma had adequate intraocular pressure (IOP) control with one medication. Three eyes underwent transscleral diode cyclophotocoagulation and maintained IOP without medications. Three eyes underwent trabeculectomy and trabeculotomy, trabeculectomy followed by penetrating keratoplasty, and trabeculectomy, respectively, of which two eyes became phthisical. At the last follow-up, the median (IQR) IOP was 14 mm Hg (IQR, 14-17) Hg. The median (IQR) follow-up duration was 4.53 months (IQR, 2.03- 48.06). CONCLUSION: One-fifth of the eyes with congenital aphakia had secondary developmental glaucoma. The corneal diameter and axial lengths were higher in the eyes with glaucoma compared to eyes without glaucoma. Medical management is the preferred short-term mode of IOP control. Transscleral cyclophotocoagulation may be preferred over surgical intervention.
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spelling pubmed-91146122022-05-19 Secondary developmental glaucoma in eyes with congenital aphakia Badakere, Swathi Vallabh Aulakh, Simranjeet Achanta, Divya Sree Ramya Chary, Raghava Senthil, Sirisha Chaurasia, Sunita Ramappa, Muralidhar Edward, Deepak P Indian J Ophthalmol Original Article PURPOSE: To describe the clinical spectrum and management of glaucoma in congenital aphakia. METHODS: The demographics and clinical spectrum of eyes with congenital aphakia with and without glaucoma were compared, and management outcomes of congenital aphakia cases with glaucoma were studied retrospectively between April 2000 and June 2020. RESULTS: There were a total of 168 eyes (84 subjects) with a diagnosis of congenital aphakia, of which 29 eyes of 18 subjects were diagnosed with glaucoma. Corneal opacity was the presenting complaint in 26/29 eyes with glaucoma and 139/139 eyes without glaucoma. The (interquartile range (IQR)) horizontal corneal diameter was 10.5mm (IQR, 9.0-12.5) and 8mm (IQR, 5-10) in eyes with and without glaucoma (P = 0.01), respectively. The median (IQR) axial length was 17.5mm (IQR, 13.5-19.5) and 15mm (IQR, 14-16) mm in eyes with and without glaucoma (P = 0.03), respectively. Nineteen eyes with glaucoma had adequate intraocular pressure (IOP) control with one medication. Three eyes underwent transscleral diode cyclophotocoagulation and maintained IOP without medications. Three eyes underwent trabeculectomy and trabeculotomy, trabeculectomy followed by penetrating keratoplasty, and trabeculectomy, respectively, of which two eyes became phthisical. At the last follow-up, the median (IQR) IOP was 14 mm Hg (IQR, 14-17) Hg. The median (IQR) follow-up duration was 4.53 months (IQR, 2.03- 48.06). CONCLUSION: One-fifth of the eyes with congenital aphakia had secondary developmental glaucoma. The corneal diameter and axial lengths were higher in the eyes with glaucoma compared to eyes without glaucoma. Medical management is the preferred short-term mode of IOP control. Transscleral cyclophotocoagulation may be preferred over surgical intervention. Wolters Kluwer - Medknow 2022-03 2022-02-25 /pmc/articles/PMC9114612/ /pubmed/35225525 http://dx.doi.org/10.4103/ijo.IJO_1782_21 Text en Copyright: © 2022 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Badakere, Swathi Vallabh
Aulakh, Simranjeet
Achanta, Divya Sree Ramya
Chary, Raghava
Senthil, Sirisha
Chaurasia, Sunita
Ramappa, Muralidhar
Edward, Deepak P
Secondary developmental glaucoma in eyes with congenital aphakia
title Secondary developmental glaucoma in eyes with congenital aphakia
title_full Secondary developmental glaucoma in eyes with congenital aphakia
title_fullStr Secondary developmental glaucoma in eyes with congenital aphakia
title_full_unstemmed Secondary developmental glaucoma in eyes with congenital aphakia
title_short Secondary developmental glaucoma in eyes with congenital aphakia
title_sort secondary developmental glaucoma in eyes with congenital aphakia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114612/
https://www.ncbi.nlm.nih.gov/pubmed/35225525
http://dx.doi.org/10.4103/ijo.IJO_1782_21
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