Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review

In the past decade, the incidence of recurrent pregnancy loss (RPL) has increased significantly, and immunological disorders have been considered as one of the possible causes contributing to RPL. The presence of antinuclear antibodies (ANAs) is regarded as a typical antibody of autoimmunity. Howeve...

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Autores principales: Liu, Ting, Guo, Xi, Liao, Ying, Liu, Yingyu, Zhu, Yuanfang, Chen, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114698/
https://www.ncbi.nlm.nih.gov/pubmed/35600596
http://dx.doi.org/10.3389/fendo.2022.873286
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author Liu, Ting
Guo, Xi
Liao, Ying
Liu, Yingyu
Zhu, Yuanfang
Chen, Xiaoyan
author_facet Liu, Ting
Guo, Xi
Liao, Ying
Liu, Yingyu
Zhu, Yuanfang
Chen, Xiaoyan
author_sort Liu, Ting
collection PubMed
description In the past decade, the incidence of recurrent pregnancy loss (RPL) has increased significantly, and immunological disorders have been considered as one of the possible causes contributing to RPL. The presence of antinuclear antibodies (ANAs) is regarded as a typical antibody of autoimmunity. However, the relationship between the presence of ANAs and RPL, the underlying mechanism, and the possible role of immunotherapy is still controversial. The aim of this mini review is to assess the association between ANAs and RPL and the effects of immunotherapy on pregnancy outcomes in women with positive ANAs and a history of RPL from the available data and to provide a relevant reference basis for clinical application in this group of women.
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spelling pubmed-91146982022-05-19 Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review Liu, Ting Guo, Xi Liao, Ying Liu, Yingyu Zhu, Yuanfang Chen, Xiaoyan Front Endocrinol (Lausanne) Endocrinology In the past decade, the incidence of recurrent pregnancy loss (RPL) has increased significantly, and immunological disorders have been considered as one of the possible causes contributing to RPL. The presence of antinuclear antibodies (ANAs) is regarded as a typical antibody of autoimmunity. However, the relationship between the presence of ANAs and RPL, the underlying mechanism, and the possible role of immunotherapy is still controversial. The aim of this mini review is to assess the association between ANAs and RPL and the effects of immunotherapy on pregnancy outcomes in women with positive ANAs and a history of RPL from the available data and to provide a relevant reference basis for clinical application in this group of women. Frontiers Media S.A. 2022-05-04 /pmc/articles/PMC9114698/ /pubmed/35600596 http://dx.doi.org/10.3389/fendo.2022.873286 Text en Copyright © 2022 Liu, Guo, Liao, Liu, Zhu and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Liu, Ting
Guo, Xi
Liao, Ying
Liu, Yingyu
Zhu, Yuanfang
Chen, Xiaoyan
Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review
title Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review
title_full Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review
title_fullStr Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review
title_full_unstemmed Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review
title_short Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review
title_sort correlation between the presence of antinuclear antibodies and recurrent pregnancy loss: a mini review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114698/
https://www.ncbi.nlm.nih.gov/pubmed/35600596
http://dx.doi.org/10.3389/fendo.2022.873286
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