Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer

Exosomes, a type of extracellular vesicles (EVs), are secreted by almost all cells and contain many cellular constituents, such as nucleic acids, lipids, and metabolites. In addition, they play a crucial role in intercellular communication and have been proved to be involved in the development and t...

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Autores principales: Kang, Fanhua, Jiang, Feng, Ouyang, Lingzi, Wu, Shangjun, Fu, Chencheng, Liu, Ying, Li, Zhilan, Tian, Yu, Cao, Xiaolan, Wang, Xiaoping, He, Qingchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114804/
https://www.ncbi.nlm.nih.gov/pubmed/35602607
http://dx.doi.org/10.3389/fcell.2022.886191
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author Kang, Fanhua
Jiang, Feng
Ouyang, Lingzi
Wu, Shangjun
Fu, Chencheng
Liu, Ying
Li, Zhilan
Tian, Yu
Cao, Xiaolan
Wang, Xiaoping
He, Qingchun
author_facet Kang, Fanhua
Jiang, Feng
Ouyang, Lingzi
Wu, Shangjun
Fu, Chencheng
Liu, Ying
Li, Zhilan
Tian, Yu
Cao, Xiaolan
Wang, Xiaoping
He, Qingchun
author_sort Kang, Fanhua
collection PubMed
description Exosomes, a type of extracellular vesicles (EVs), are secreted by almost all cells and contain many cellular constituents, such as nucleic acids, lipids, and metabolites. In addition, they play a crucial role in intercellular communication and have been proved to be involved in the development and treatment of gastrointestinal cancer. It has been confirmed that long non-coding RNAs (lncRNAs) exert a range of biological functions, such as cell metastasis, tumorigenesis, and therapeutic responses. This review mainly focused on the emerging roles and underlying molecular mechanisms of exosome-derived lncRNAs in gastrointestinal cancer in recent years. The biological roles of exosomal lncRNAs in the pathogenesis and therapeutic responses of gastrointestinal cancers were also investigated.
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spelling pubmed-91148042022-05-19 Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer Kang, Fanhua Jiang, Feng Ouyang, Lingzi Wu, Shangjun Fu, Chencheng Liu, Ying Li, Zhilan Tian, Yu Cao, Xiaolan Wang, Xiaoping He, Qingchun Front Cell Dev Biol Cell and Developmental Biology Exosomes, a type of extracellular vesicles (EVs), are secreted by almost all cells and contain many cellular constituents, such as nucleic acids, lipids, and metabolites. In addition, they play a crucial role in intercellular communication and have been proved to be involved in the development and treatment of gastrointestinal cancer. It has been confirmed that long non-coding RNAs (lncRNAs) exert a range of biological functions, such as cell metastasis, tumorigenesis, and therapeutic responses. This review mainly focused on the emerging roles and underlying molecular mechanisms of exosome-derived lncRNAs in gastrointestinal cancer in recent years. The biological roles of exosomal lncRNAs in the pathogenesis and therapeutic responses of gastrointestinal cancers were also investigated. Frontiers Media S.A. 2022-05-04 /pmc/articles/PMC9114804/ /pubmed/35602607 http://dx.doi.org/10.3389/fcell.2022.886191 Text en Copyright © 2022 Kang, Jiang, Ouyang, Wu, Fu, Liu, Li, Tian, Cao, Wang and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Kang, Fanhua
Jiang, Feng
Ouyang, Lingzi
Wu, Shangjun
Fu, Chencheng
Liu, Ying
Li, Zhilan
Tian, Yu
Cao, Xiaolan
Wang, Xiaoping
He, Qingchun
Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer
title Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer
title_full Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer
title_fullStr Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer
title_full_unstemmed Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer
title_short Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer
title_sort potential biological roles of exosomal long non-coding rnas in gastrointestinal cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114804/
https://www.ncbi.nlm.nih.gov/pubmed/35602607
http://dx.doi.org/10.3389/fcell.2022.886191
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