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Increase of Deep Intraepithelial Lymphocytes in the Oxyntic Mucosa of Patients With Potential and Overt Autoimmune Gastritis
Pathological correlates of potential autoimmune gastritis (AIG), defined by anti-parietal cell antibody (PCA) positivity in the absence of gastric atrophy, have never been described. We herein aimed to assess intraepithelial lymphocyte (IEL) infiltration in gastric corpus of AIG patients. From 2000...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114815/ https://www.ncbi.nlm.nih.gov/pubmed/35603187 http://dx.doi.org/10.3389/fimmu.2022.866167 |
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author | Lenti, Marco Vincenzo Vanoli, Alessandro Miceli, Emanuela Arpa, Giovanni Di Stefano, Michele Soriano, Simone Capuano, Francesca Gentile, Antonella Aronico, Nicola Coppola, Luigi Pasini, Alessandra Luinetti, Ombretta Mauro, Aurelio Paulli, Marco Klersy, Catherine Corazza, Gino Roberto Di Sabatino, Antonio |
author_facet | Lenti, Marco Vincenzo Vanoli, Alessandro Miceli, Emanuela Arpa, Giovanni Di Stefano, Michele Soriano, Simone Capuano, Francesca Gentile, Antonella Aronico, Nicola Coppola, Luigi Pasini, Alessandra Luinetti, Ombretta Mauro, Aurelio Paulli, Marco Klersy, Catherine Corazza, Gino Roberto Di Sabatino, Antonio |
author_sort | Lenti, Marco Vincenzo |
collection | PubMed |
description | Pathological correlates of potential autoimmune gastritis (AIG), defined by anti-parietal cell antibody (PCA) positivity in the absence of gastric atrophy, have never been described. We herein aimed to assess intraepithelial lymphocyte (IEL) infiltration in gastric corpus of AIG patients. From 2000 to 2021, among 53 potential AIG patients, we focused on nine (median age 61 years, IQR 53-82; four females) who subsequently developed overt AIG. IEL infiltration of the oxyntic mucosa was assessed before and after developing overt AIG by measuring deep and superficial CD3+ IEL. AIG patients with different degrees of corpus atrophy, healthy controls (HC), active H. pylori gastritis, celiac disease (CD), and Hashimoto’s thyroiditis patients were included as controls. Of note, deep, but not superficial, CD3+ IEL count was higher (p<0.001) in potential AIG compared to HC and H. pylori gastritis. Deep CD3+ IEL infiltration did not change before or after the evolution into atrophy (median 9.6, IQR 8.8-12.4, vs 11.3, IQR 9.4-12.9). No difference was found in deep CD3+ IEL infiltration among potential, mild, and severe AIG, and compared to Hashimoto’s thyroiditis or CD. A deep CD3+ IEL cut-off of >7/100 epithelial cells allowed discrimination of any AIG stage and severity (AUC=0.842). We conclude that an increased deep CD3+ IEL infiltration of the oxyntic mucosa could represent a marker of potential AIG. Prospective studies including a larger number of potential AIG patients are needed. |
format | Online Article Text |
id | pubmed-9114815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91148152022-05-19 Increase of Deep Intraepithelial Lymphocytes in the Oxyntic Mucosa of Patients With Potential and Overt Autoimmune Gastritis Lenti, Marco Vincenzo Vanoli, Alessandro Miceli, Emanuela Arpa, Giovanni Di Stefano, Michele Soriano, Simone Capuano, Francesca Gentile, Antonella Aronico, Nicola Coppola, Luigi Pasini, Alessandra Luinetti, Ombretta Mauro, Aurelio Paulli, Marco Klersy, Catherine Corazza, Gino Roberto Di Sabatino, Antonio Front Immunol Immunology Pathological correlates of potential autoimmune gastritis (AIG), defined by anti-parietal cell antibody (PCA) positivity in the absence of gastric atrophy, have never been described. We herein aimed to assess intraepithelial lymphocyte (IEL) infiltration in gastric corpus of AIG patients. From 2000 to 2021, among 53 potential AIG patients, we focused on nine (median age 61 years, IQR 53-82; four females) who subsequently developed overt AIG. IEL infiltration of the oxyntic mucosa was assessed before and after developing overt AIG by measuring deep and superficial CD3+ IEL. AIG patients with different degrees of corpus atrophy, healthy controls (HC), active H. pylori gastritis, celiac disease (CD), and Hashimoto’s thyroiditis patients were included as controls. Of note, deep, but not superficial, CD3+ IEL count was higher (p<0.001) in potential AIG compared to HC and H. pylori gastritis. Deep CD3+ IEL infiltration did not change before or after the evolution into atrophy (median 9.6, IQR 8.8-12.4, vs 11.3, IQR 9.4-12.9). No difference was found in deep CD3+ IEL infiltration among potential, mild, and severe AIG, and compared to Hashimoto’s thyroiditis or CD. A deep CD3+ IEL cut-off of >7/100 epithelial cells allowed discrimination of any AIG stage and severity (AUC=0.842). We conclude that an increased deep CD3+ IEL infiltration of the oxyntic mucosa could represent a marker of potential AIG. Prospective studies including a larger number of potential AIG patients are needed. Frontiers Media S.A. 2022-05-04 /pmc/articles/PMC9114815/ /pubmed/35603187 http://dx.doi.org/10.3389/fimmu.2022.866167 Text en Copyright © 2022 Lenti, Vanoli, Miceli, Arpa, Di Stefano, Soriano, Capuano, Gentile, Aronico, Coppola, Pasini, Luinetti, Mauro, Paulli, Klersy, Corazza and Di Sabatino https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lenti, Marco Vincenzo Vanoli, Alessandro Miceli, Emanuela Arpa, Giovanni Di Stefano, Michele Soriano, Simone Capuano, Francesca Gentile, Antonella Aronico, Nicola Coppola, Luigi Pasini, Alessandra Luinetti, Ombretta Mauro, Aurelio Paulli, Marco Klersy, Catherine Corazza, Gino Roberto Di Sabatino, Antonio Increase of Deep Intraepithelial Lymphocytes in the Oxyntic Mucosa of Patients With Potential and Overt Autoimmune Gastritis |
title | Increase of Deep Intraepithelial Lymphocytes in the Oxyntic Mucosa of Patients With Potential and Overt Autoimmune Gastritis |
title_full | Increase of Deep Intraepithelial Lymphocytes in the Oxyntic Mucosa of Patients With Potential and Overt Autoimmune Gastritis |
title_fullStr | Increase of Deep Intraepithelial Lymphocytes in the Oxyntic Mucosa of Patients With Potential and Overt Autoimmune Gastritis |
title_full_unstemmed | Increase of Deep Intraepithelial Lymphocytes in the Oxyntic Mucosa of Patients With Potential and Overt Autoimmune Gastritis |
title_short | Increase of Deep Intraepithelial Lymphocytes in the Oxyntic Mucosa of Patients With Potential and Overt Autoimmune Gastritis |
title_sort | increase of deep intraepithelial lymphocytes in the oxyntic mucosa of patients with potential and overt autoimmune gastritis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114815/ https://www.ncbi.nlm.nih.gov/pubmed/35603187 http://dx.doi.org/10.3389/fimmu.2022.866167 |
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