Inconsistency between overall and subgroup analyses

Suppose we have a sample of subjects in two treatment groups. To study the difference of the treatment effects, we can analyse the data using all subjects (overall analysis). We may also divide the subjects into several subgroups based on some covariates of interest (eg, gender), and study the treat...

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Detalles Bibliográficos
Autores principales: Wang, Hongyue, Wang, Bokai, Tu, Xin M, Feng, Changyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Biostatistical Methods in Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114839/
https://www.ncbi.nlm.nih.gov/pubmed/35677850
http://dx.doi.org/10.1136/gpsych-2021-100732
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author Wang, Hongyue
Wang, Bokai
Tu, Xin M
Feng, Changyong
author_facet Wang, Hongyue
Wang, Bokai
Tu, Xin M
Feng, Changyong
author_sort Wang, Hongyue
collection PubMed
description Suppose we have a sample of subjects in two treatment groups. To study the difference of the treatment effects, we can analyse the data using all subjects (overall analysis). We may also divide the subjects into several subgroups based on some covariates of interest (eg, gender), and study the treatment effects within each subgroup. The results of these two analyses may be different or even in opposite directions. In this paper, we give a general sufficient condition of consistency between the overall and subgroup analyses.
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spelling pubmed-91148392022-06-07 Inconsistency between overall and subgroup analyses Wang, Hongyue Wang, Bokai Tu, Xin M Feng, Changyong Gen Psychiatr Biostatistical Methods in Psychiatry Suppose we have a sample of subjects in two treatment groups. To study the difference of the treatment effects, we can analyse the data using all subjects (overall analysis). We may also divide the subjects into several subgroups based on some covariates of interest (eg, gender), and study the treatment effects within each subgroup. The results of these two analyses may be different or even in opposite directions. In this paper, we give a general sufficient condition of consistency between the overall and subgroup analyses. BMJ Publishing Group 2022-05-16 /pmc/articles/PMC9114839/ /pubmed/35677850 http://dx.doi.org/10.1136/gpsych-2021-100732 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Biostatistical Methods in Psychiatry
Wang, Hongyue
Wang, Bokai
Tu, Xin M
Feng, Changyong
Inconsistency between overall and subgroup analyses
title Inconsistency between overall and subgroup analyses
title_full Inconsistency between overall and subgroup analyses
title_fullStr Inconsistency between overall and subgroup analyses
title_full_unstemmed Inconsistency between overall and subgroup analyses
title_short Inconsistency between overall and subgroup analyses
title_sort inconsistency between overall and subgroup analyses
topic Biostatistical Methods in Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114839/
https://www.ncbi.nlm.nih.gov/pubmed/35677850
http://dx.doi.org/10.1136/gpsych-2021-100732
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