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High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair
Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior. However, which factors contribute to these increases and whether the increases are sufficient to induce depressive-like behaviors is unclear. To beg...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114865/ https://www.ncbi.nlm.nih.gov/pubmed/35601829 http://dx.doi.org/10.3389/fmolb.2022.859760 |
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author | Sambolín-Escobales, Lubriel Tirado-Castro, Lizmarie Suarez, Cristina Pacheco-Cruz, Dariangelly Fonseca-Ferrer, Wilfred Deme, Pragney Haughey, Norman Chompre, Gladys Porter, James T. |
author_facet | Sambolín-Escobales, Lubriel Tirado-Castro, Lizmarie Suarez, Cristina Pacheco-Cruz, Dariangelly Fonseca-Ferrer, Wilfred Deme, Pragney Haughey, Norman Chompre, Gladys Porter, James T. |
author_sort | Sambolín-Escobales, Lubriel |
collection | PubMed |
description | Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior. However, which factors contribute to these increases and whether the increases are sufficient to induce depressive-like behaviors is unclear. To begin to address this issue, we examined the effects of high fat diet (HFD) and short-term unpredictable (STU) stress on long-chain ceramides in the serum of male and female rats. We found that brief exposure to HFD or unpredictable stress was sufficient to induce selective increases in the serum concentrations of long-chain ceramides, associated with depression in people. Furthermore, combined exposure to HFD and unpredictable stress caused a synergistic increase in C16:0, C16:1, and C18:0 ceramides in both sexes and C18:1 and C24:1 in males. However, the increased peripheral long-chain ceramides were not associated with increases in depressive-like behaviors suggesting that increases in serum long-chain ceramides may not be associated with the development of depressive-like behaviors in rodents. |
format | Online Article Text |
id | pubmed-9114865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91148652022-05-19 High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair Sambolín-Escobales, Lubriel Tirado-Castro, Lizmarie Suarez, Cristina Pacheco-Cruz, Dariangelly Fonseca-Ferrer, Wilfred Deme, Pragney Haughey, Norman Chompre, Gladys Porter, James T. Front Mol Biosci Molecular Biosciences Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior. However, which factors contribute to these increases and whether the increases are sufficient to induce depressive-like behaviors is unclear. To begin to address this issue, we examined the effects of high fat diet (HFD) and short-term unpredictable (STU) stress on long-chain ceramides in the serum of male and female rats. We found that brief exposure to HFD or unpredictable stress was sufficient to induce selective increases in the serum concentrations of long-chain ceramides, associated with depression in people. Furthermore, combined exposure to HFD and unpredictable stress caused a synergistic increase in C16:0, C16:1, and C18:0 ceramides in both sexes and C18:1 and C24:1 in males. However, the increased peripheral long-chain ceramides were not associated with increases in depressive-like behaviors suggesting that increases in serum long-chain ceramides may not be associated with the development of depressive-like behaviors in rodents. Frontiers Media S.A. 2022-05-04 /pmc/articles/PMC9114865/ /pubmed/35601829 http://dx.doi.org/10.3389/fmolb.2022.859760 Text en Copyright © 2022 Sambolín-Escobales, Tirado-Castro, Suarez, Pacheco-Cruz, Fonseca-Ferrer, Deme, Haughey, Chompre and Porter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Sambolín-Escobales, Lubriel Tirado-Castro, Lizmarie Suarez, Cristina Pacheco-Cruz, Dariangelly Fonseca-Ferrer, Wilfred Deme, Pragney Haughey, Norman Chompre, Gladys Porter, James T. High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair |
title | High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair |
title_full | High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair |
title_fullStr | High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair |
title_full_unstemmed | High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair |
title_short | High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair |
title_sort | high-fat diet and short-term unpredictable stress increase long-chain ceramides without enhancing behavioral despair |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114865/ https://www.ncbi.nlm.nih.gov/pubmed/35601829 http://dx.doi.org/10.3389/fmolb.2022.859760 |
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