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High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair

Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior. However, which factors contribute to these increases and whether the increases are sufficient to induce depressive-like behaviors is unclear. To beg...

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Autores principales: Sambolín-Escobales, Lubriel, Tirado-Castro, Lizmarie, Suarez, Cristina, Pacheco-Cruz, Dariangelly, Fonseca-Ferrer, Wilfred, Deme, Pragney, Haughey, Norman, Chompre, Gladys, Porter, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114865/
https://www.ncbi.nlm.nih.gov/pubmed/35601829
http://dx.doi.org/10.3389/fmolb.2022.859760
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author Sambolín-Escobales, Lubriel
Tirado-Castro, Lizmarie
Suarez, Cristina
Pacheco-Cruz, Dariangelly
Fonseca-Ferrer, Wilfred
Deme, Pragney
Haughey, Norman
Chompre, Gladys
Porter, James T.
author_facet Sambolín-Escobales, Lubriel
Tirado-Castro, Lizmarie
Suarez, Cristina
Pacheco-Cruz, Dariangelly
Fonseca-Ferrer, Wilfred
Deme, Pragney
Haughey, Norman
Chompre, Gladys
Porter, James T.
author_sort Sambolín-Escobales, Lubriel
collection PubMed
description Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior. However, which factors contribute to these increases and whether the increases are sufficient to induce depressive-like behaviors is unclear. To begin to address this issue, we examined the effects of high fat diet (HFD) and short-term unpredictable (STU) stress on long-chain ceramides in the serum of male and female rats. We found that brief exposure to HFD or unpredictable stress was sufficient to induce selective increases in the serum concentrations of long-chain ceramides, associated with depression in people. Furthermore, combined exposure to HFD and unpredictable stress caused a synergistic increase in C16:0, C16:1, and C18:0 ceramides in both sexes and C18:1 and C24:1 in males. However, the increased peripheral long-chain ceramides were not associated with increases in depressive-like behaviors suggesting that increases in serum long-chain ceramides may not be associated with the development of depressive-like behaviors in rodents.
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spelling pubmed-91148652022-05-19 High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair Sambolín-Escobales, Lubriel Tirado-Castro, Lizmarie Suarez, Cristina Pacheco-Cruz, Dariangelly Fonseca-Ferrer, Wilfred Deme, Pragney Haughey, Norman Chompre, Gladys Porter, James T. Front Mol Biosci Molecular Biosciences Clinical and preclinical studies suggest that increases in long-chain ceramides in blood may contribute to the development of depressive-like behavior. However, which factors contribute to these increases and whether the increases are sufficient to induce depressive-like behaviors is unclear. To begin to address this issue, we examined the effects of high fat diet (HFD) and short-term unpredictable (STU) stress on long-chain ceramides in the serum of male and female rats. We found that brief exposure to HFD or unpredictable stress was sufficient to induce selective increases in the serum concentrations of long-chain ceramides, associated with depression in people. Furthermore, combined exposure to HFD and unpredictable stress caused a synergistic increase in C16:0, C16:1, and C18:0 ceramides in both sexes and C18:1 and C24:1 in males. However, the increased peripheral long-chain ceramides were not associated with increases in depressive-like behaviors suggesting that increases in serum long-chain ceramides may not be associated with the development of depressive-like behaviors in rodents. Frontiers Media S.A. 2022-05-04 /pmc/articles/PMC9114865/ /pubmed/35601829 http://dx.doi.org/10.3389/fmolb.2022.859760 Text en Copyright © 2022 Sambolín-Escobales, Tirado-Castro, Suarez, Pacheco-Cruz, Fonseca-Ferrer, Deme, Haughey, Chompre and Porter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Sambolín-Escobales, Lubriel
Tirado-Castro, Lizmarie
Suarez, Cristina
Pacheco-Cruz, Dariangelly
Fonseca-Ferrer, Wilfred
Deme, Pragney
Haughey, Norman
Chompre, Gladys
Porter, James T.
High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair
title High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair
title_full High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair
title_fullStr High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair
title_full_unstemmed High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair
title_short High-Fat Diet and Short-Term Unpredictable Stress Increase Long-Chain Ceramides Without Enhancing Behavioral Despair
title_sort high-fat diet and short-term unpredictable stress increase long-chain ceramides without enhancing behavioral despair
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9114865/
https://www.ncbi.nlm.nih.gov/pubmed/35601829
http://dx.doi.org/10.3389/fmolb.2022.859760
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