Time to evolve: predicting engineered T cell-associated toxicity with next-generation models

Despite promising clinical results in a small subset of malignancies, therapies based on engineered chimeric antigen receptor and T-cell receptor T cells are associated with serious adverse events, including cytokine release syndrome and neurotoxicity. These toxicities are sometimes so severe that t...

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Detalles Bibliográficos
Autores principales: Donnadieu, Emmanuel, Luu, Maik, Alb, Miriam, Anliker, Brigitte, Arcangeli, Silvia, Bonini, Chiara, De Angelis, Biagio, Choudhary, Rashmi, Espie, David, Galy, Anne, Holland, Cam, Ivics, Zoltán, Kantari-Mimoun, Chahrazade, Kersten, Marie Jose, Köhl, Ulrike, Kuhn, Chantal, Laugel, Bruno, Locatelli, Franco, Marchiq, Ibtissam, Markman, Janet, Moresco, Marta Angiola, Morris, Emma, Negre, Helene, Quintarelli, Concetta, Rade, Michael, Reiche, Kristin, Renner, Matthias, Ruggiero, Eliana, Sanges, Carmen, Stauss, Hans, Themeli, Maria, Van den Brulle, Jan, Hudecek, Michael, Casucci, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115021/
https://www.ncbi.nlm.nih.gov/pubmed/35577500
http://dx.doi.org/10.1136/jitc-2021-003486

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