Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models

Podocalyxin (Podxl) is a CD34-related cell surface sialomucin that is normally highly expressed by adult vascular endothelia and kidney podocytes where it plays a key role in blocking adhesion. Importantly, it is also frequently upregulated on a wide array of human tumors and its expression often co...

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Detalles Bibliográficos
Autores principales: Canals Hernaez, Diana, Hughes, Michael R., Li, Yicong, Mainero Rocca, Ilaria, Dean, Pamela, Brassard, Julyanne, Bell, Erin M., Samudio, Ismael, Mes-Masson, Anne-Marie, Narimatsu, Yoshiki, Clausen, Henrik, Blixt, Ola, Roskelley, Calvin D., McNagny, Kelly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115113/
https://www.ncbi.nlm.nih.gov/pubmed/35600398
http://dx.doi.org/10.3389/fonc.2022.856424

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