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Successful control of Candida auris transmission in a German COVID‐19 intensive care unit
BACKGROUND: Candida auris a frequently multidrug‐resistant yeast species that poses a global health threat due to its high potential for hospital outbreaks. While C. auris has become endemic in parts of Asia and Africa, transmissions have so far rarely been reported in Western Europe except for Grea...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115290/ https://www.ncbi.nlm.nih.gov/pubmed/35419847 http://dx.doi.org/10.1111/myc.13443 |
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author | Hinrichs, Carl Wiese‐Posselt, Miriam Graf, Barbara Geffers, Christine Weikert, Beate Enghard, Philipp Aldejohann, Alexander Schrauder, Annette Knaust, Andreas Eckardt, Kai‐Uwe Gastmeier, Petra Kurzai, Oliver |
author_facet | Hinrichs, Carl Wiese‐Posselt, Miriam Graf, Barbara Geffers, Christine Weikert, Beate Enghard, Philipp Aldejohann, Alexander Schrauder, Annette Knaust, Andreas Eckardt, Kai‐Uwe Gastmeier, Petra Kurzai, Oliver |
author_sort | Hinrichs, Carl |
collection | PubMed |
description | BACKGROUND: Candida auris a frequently multidrug‐resistant yeast species that poses a global health threat due to its high potential for hospital outbreaks. While C. auris has become endemic in parts of Asia and Africa, transmissions have so far rarely been reported in Western Europe except for Great Britain and Spain. We describe the first documented patient‐to‐patient transmission of C. auris in Germany in a COVID‐19 intensive care unit (ICU) and infection control measures implemented to prevent further spread of the pathogen. METHODS: Identification of C. auris was performed by MALDI‐TOF and confirmed by internal transcribed spacer (ITS) sequencing. Antifungal susceptibility testing was carried out. We conducted repeated cross‐sectional examinations for the presence of C. auris in the patients of the affected ICU and investigated possible routes of transmission. RESULTS: The index patient had been transferred to Germany from a hospital in Northern Africa and was found to be colonised with C. auris. The contact patient developed C. auris sepsis. Infection prevention and control (IPC) measures included strict isolation of the two C. auris patients and regular screening of non‐affected patients. No further case occurred during the subsequent weeks. Reusable blades used in video laryngoscope‐guided intubation were considered as the most likely vehicle of transmission. CONCLUSIONS: In view of its high risk of transmission, vigilance regarding C. auris colonisation in patients referred from endemic countries is crucial. Strict and immediate IPC measures may have the potential to prevent C. auris outbreaks. |
format | Online Article Text |
id | pubmed-9115290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91152902022-05-18 Successful control of Candida auris transmission in a German COVID‐19 intensive care unit Hinrichs, Carl Wiese‐Posselt, Miriam Graf, Barbara Geffers, Christine Weikert, Beate Enghard, Philipp Aldejohann, Alexander Schrauder, Annette Knaust, Andreas Eckardt, Kai‐Uwe Gastmeier, Petra Kurzai, Oliver Mycoses Original Articles BACKGROUND: Candida auris a frequently multidrug‐resistant yeast species that poses a global health threat due to its high potential for hospital outbreaks. While C. auris has become endemic in parts of Asia and Africa, transmissions have so far rarely been reported in Western Europe except for Great Britain and Spain. We describe the first documented patient‐to‐patient transmission of C. auris in Germany in a COVID‐19 intensive care unit (ICU) and infection control measures implemented to prevent further spread of the pathogen. METHODS: Identification of C. auris was performed by MALDI‐TOF and confirmed by internal transcribed spacer (ITS) sequencing. Antifungal susceptibility testing was carried out. We conducted repeated cross‐sectional examinations for the presence of C. auris in the patients of the affected ICU and investigated possible routes of transmission. RESULTS: The index patient had been transferred to Germany from a hospital in Northern Africa and was found to be colonised with C. auris. The contact patient developed C. auris sepsis. Infection prevention and control (IPC) measures included strict isolation of the two C. auris patients and regular screening of non‐affected patients. No further case occurred during the subsequent weeks. Reusable blades used in video laryngoscope‐guided intubation were considered as the most likely vehicle of transmission. CONCLUSIONS: In view of its high risk of transmission, vigilance regarding C. auris colonisation in patients referred from endemic countries is crucial. Strict and immediate IPC measures may have the potential to prevent C. auris outbreaks. John Wiley and Sons Inc. 2022-04-24 2022-06 /pmc/articles/PMC9115290/ /pubmed/35419847 http://dx.doi.org/10.1111/myc.13443 Text en © 2022 The Authors. Mycoses published by Wiley‐VCH GmbH. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Hinrichs, Carl Wiese‐Posselt, Miriam Graf, Barbara Geffers, Christine Weikert, Beate Enghard, Philipp Aldejohann, Alexander Schrauder, Annette Knaust, Andreas Eckardt, Kai‐Uwe Gastmeier, Petra Kurzai, Oliver Successful control of Candida auris transmission in a German COVID‐19 intensive care unit |
title | Successful control of Candida auris transmission in a German COVID‐19 intensive care unit |
title_full | Successful control of Candida auris transmission in a German COVID‐19 intensive care unit |
title_fullStr | Successful control of Candida auris transmission in a German COVID‐19 intensive care unit |
title_full_unstemmed | Successful control of Candida auris transmission in a German COVID‐19 intensive care unit |
title_short | Successful control of Candida auris transmission in a German COVID‐19 intensive care unit |
title_sort | successful control of candida auris transmission in a german covid‐19 intensive care unit |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115290/ https://www.ncbi.nlm.nih.gov/pubmed/35419847 http://dx.doi.org/10.1111/myc.13443 |
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