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Sensitivity Analysis of Excess Mortality due to the COVID‐19 Pandemic

Estimating excess mortality is challenging. The metric depends on the expected mortality level, which can differ based on given choices, such as the method and the time series length used to estimate the baseline. However, these choices are often arbitrary, and are not subject to any sensitivity ana...

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Autores principales: Nepomuceno, Marília R., Klimkin, Ilya, Jdanov, Dmitri A., Alustiza‐Galarza, Ainhoa, Shkolnikov, Vladimir M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115405/
https://www.ncbi.nlm.nih.gov/pubmed/35600716
http://dx.doi.org/10.1111/padr.12475
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author Nepomuceno, Marília R.
Klimkin, Ilya
Jdanov, Dmitri A.
Alustiza‐Galarza, Ainhoa
Shkolnikov, Vladimir M.
author_facet Nepomuceno, Marília R.
Klimkin, Ilya
Jdanov, Dmitri A.
Alustiza‐Galarza, Ainhoa
Shkolnikov, Vladimir M.
author_sort Nepomuceno, Marília R.
collection PubMed
description Estimating excess mortality is challenging. The metric depends on the expected mortality level, which can differ based on given choices, such as the method and the time series length used to estimate the baseline. However, these choices are often arbitrary, and are not subject to any sensitivity analysis. We bring to light the importance of carefully choosing the inputs and methods used to estimate excess mortality. Drawing on data from 26 countries, we investigate how sensitive excess mortality is to the choice of the mortality index, the number of years included in the reference period, the method, and the time unit of the death series. We employ two mortality indices, three reference periods, two data time units, and four methods for estimating the baseline. We show that excess mortality estimates can vary substantially when these factors are changed, and that the largest variations stem from the choice of the mortality index and the method. We also find that the magnitude of the variation in excess mortality is country‐specific, resulting in cross‐country rankings changes. Finally, based on our findings, we provide guidelines for estimating excess mortality.
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spelling pubmed-91154052022-05-18 Sensitivity Analysis of Excess Mortality due to the COVID‐19 Pandemic Nepomuceno, Marília R. Klimkin, Ilya Jdanov, Dmitri A. Alustiza‐Galarza, Ainhoa Shkolnikov, Vladimir M. Popul Dev Rev Articles Estimating excess mortality is challenging. The metric depends on the expected mortality level, which can differ based on given choices, such as the method and the time series length used to estimate the baseline. However, these choices are often arbitrary, and are not subject to any sensitivity analysis. We bring to light the importance of carefully choosing the inputs and methods used to estimate excess mortality. Drawing on data from 26 countries, we investigate how sensitive excess mortality is to the choice of the mortality index, the number of years included in the reference period, the method, and the time unit of the death series. We employ two mortality indices, three reference periods, two data time units, and four methods for estimating the baseline. We show that excess mortality estimates can vary substantially when these factors are changed, and that the largest variations stem from the choice of the mortality index and the method. We also find that the magnitude of the variation in excess mortality is country‐specific, resulting in cross‐country rankings changes. Finally, based on our findings, we provide guidelines for estimating excess mortality. John Wiley and Sons Inc. 2022-03-03 2022-06 /pmc/articles/PMC9115405/ /pubmed/35600716 http://dx.doi.org/10.1111/padr.12475 Text en © 2022 The Authors. Population and Development Review published by Wiley Periodicals LLC on behalf of Population Council. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Nepomuceno, Marília R.
Klimkin, Ilya
Jdanov, Dmitri A.
Alustiza‐Galarza, Ainhoa
Shkolnikov, Vladimir M.
Sensitivity Analysis of Excess Mortality due to the COVID‐19 Pandemic
title Sensitivity Analysis of Excess Mortality due to the COVID‐19 Pandemic
title_full Sensitivity Analysis of Excess Mortality due to the COVID‐19 Pandemic
title_fullStr Sensitivity Analysis of Excess Mortality due to the COVID‐19 Pandemic
title_full_unstemmed Sensitivity Analysis of Excess Mortality due to the COVID‐19 Pandemic
title_short Sensitivity Analysis of Excess Mortality due to the COVID‐19 Pandemic
title_sort sensitivity analysis of excess mortality due to the covid‐19 pandemic
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115405/
https://www.ncbi.nlm.nih.gov/pubmed/35600716
http://dx.doi.org/10.1111/padr.12475
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