Synthesis and Biological Evaluations of Betulinic Acid Derivatives With Inhibitory Activity on Hyaluronidase and Anti-Inflammatory Effects Against Hyaluronic Acid Fragment Induced Inflammation

We previously reported that the structural modifications of pentacyclic triterpenoids including oleanolic acid resulted in enhanced hyaluronidase inhibitory activity but whether this applies to other pentacyclic triterpenoids such as betulinic acid (BA) is unknown. Herein, we synthesized BA derivati...

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Detalles Bibliográficos
Autores principales: Luo, Zhujun, He, Hao, Tang, Tiantian, Zhou, Jun, Li, Huifang, Seeram, Navindra P., Li, Dongli, Zhang, Kun, Ma, Hang, Wu, Panpan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115581/
https://www.ncbi.nlm.nih.gov/pubmed/35601554
http://dx.doi.org/10.3389/fchem.2022.892554

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