Promising Role of Emodin as Therapeutics to Against Viral Infections

Emodin is an anthraquinone derivative that is widely present in natural plants and has a wide spectrum of pharmacological effects, such as antibacterial, anti-inflammatory, anti-fibrotic and anticancer and so on. Through reviewing studies on antiviral effect of emodin in the past decades, we found t...

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Autores principales: Shao, Qingqing, Liu, Tong, Wang, Wenjia, Liu, Tianli, Jin, Ximing, Chen, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115582/
https://www.ncbi.nlm.nih.gov/pubmed/35600857
http://dx.doi.org/10.3389/fphar.2022.902626
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author Shao, Qingqing
Liu, Tong
Wang, Wenjia
Liu, Tianli
Jin, Ximing
Chen, Zhuo
author_facet Shao, Qingqing
Liu, Tong
Wang, Wenjia
Liu, Tianli
Jin, Ximing
Chen, Zhuo
author_sort Shao, Qingqing
collection PubMed
description Emodin is an anthraquinone derivative that is widely present in natural plants and has a wide spectrum of pharmacological effects, such as antibacterial, anti-inflammatory, anti-fibrotic and anticancer and so on. Through reviewing studies on antiviral effect of emodin in the past decades, we found that emodin exhibits ability of inhibiting the infection and replication of more than 10 viruses in vitro and in vivo, including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), coxsackievirus B (CVB), hepatitis B virus (HBV), influenza A virus (IAV), SARS-CoV, viral haemorrhagic septicaemia rhabdovirus (VHSV), enterovirus 71 (EV71), dengue virus serotype 2 (DENV-2) and Zika virus (ZIKV). Therefore, this review aims to summarize the antiviral effect of emodin, in order to provide reference and hopes to support the further investigations.
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spelling pubmed-91155822022-05-19 Promising Role of Emodin as Therapeutics to Against Viral Infections Shao, Qingqing Liu, Tong Wang, Wenjia Liu, Tianli Jin, Ximing Chen, Zhuo Front Pharmacol Pharmacology Emodin is an anthraquinone derivative that is widely present in natural plants and has a wide spectrum of pharmacological effects, such as antibacterial, anti-inflammatory, anti-fibrotic and anticancer and so on. Through reviewing studies on antiviral effect of emodin in the past decades, we found that emodin exhibits ability of inhibiting the infection and replication of more than 10 viruses in vitro and in vivo, including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), coxsackievirus B (CVB), hepatitis B virus (HBV), influenza A virus (IAV), SARS-CoV, viral haemorrhagic septicaemia rhabdovirus (VHSV), enterovirus 71 (EV71), dengue virus serotype 2 (DENV-2) and Zika virus (ZIKV). Therefore, this review aims to summarize the antiviral effect of emodin, in order to provide reference and hopes to support the further investigations. Frontiers Media S.A. 2022-05-04 /pmc/articles/PMC9115582/ /pubmed/35600857 http://dx.doi.org/10.3389/fphar.2022.902626 Text en Copyright © 2022 Shao, Liu, Wang, Liu, Jin and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Shao, Qingqing
Liu, Tong
Wang, Wenjia
Liu, Tianli
Jin, Ximing
Chen, Zhuo
Promising Role of Emodin as Therapeutics to Against Viral Infections
title Promising Role of Emodin as Therapeutics to Against Viral Infections
title_full Promising Role of Emodin as Therapeutics to Against Viral Infections
title_fullStr Promising Role of Emodin as Therapeutics to Against Viral Infections
title_full_unstemmed Promising Role of Emodin as Therapeutics to Against Viral Infections
title_short Promising Role of Emodin as Therapeutics to Against Viral Infections
title_sort promising role of emodin as therapeutics to against viral infections
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115582/
https://www.ncbi.nlm.nih.gov/pubmed/35600857
http://dx.doi.org/10.3389/fphar.2022.902626
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