Cargando…
Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy
Congenital obstructive nephropathy (CON) is one of the most common causes of chronic kidney disease in children. The aim of the study was to investigate serum and urine periostin and cytokeratin-18 (CK-18) in children with CON in relation to CON etiology, treatment, and kidney injury. We evaluated 8...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115600/ https://www.ncbi.nlm.nih.gov/pubmed/35600153 http://dx.doi.org/10.5114/ceji.2022.115687 |
_version_ | 1784709954238676992 |
---|---|
author | Turczyn, Agnieszka Krzemień, Grażyna Górska, Elżbieta Demkow, Urszula Pańczyk-Tomaszewska, Małgorzata |
author_facet | Turczyn, Agnieszka Krzemień, Grażyna Górska, Elżbieta Demkow, Urszula Pańczyk-Tomaszewska, Małgorzata |
author_sort | Turczyn, Agnieszka |
collection | PubMed |
description | Congenital obstructive nephropathy (CON) is one of the most common causes of chronic kidney disease in children. The aim of the study was to investigate serum and urine periostin and cytokeratin-18 (CK-18) in children with CON in relation to CON etiology, treatment, and kidney injury. We evaluated 81 children with CON secondary to ureteropelvic junction obstruction (UPJO), ureterovesical junction obstruction (UVJO), posterior urethral valves (PUV) and 60 controls. Neither biomarker demonstrated any relation to CON etiology. However, all patients showed significantly higher urine periostin (uPeriostin) and uPeriostin/Cr levels than the controls. Also, UVJO patients showed higher sCK-18 and uCK-18/Cr levels, and PUV patients showed higher uCK-18/Cr levels than the controls. Neither biomarker was found to have any relation to CON treatment. However, conservatively treated children and those before and after surgery showed significantly higher uPeriostin and uPeriostin/Cr levels than the controls. uPeriostin strongly correlated with differential renal function (DRF) < 40%. The ROC analysis demonstrated the best area under the curve (AUC) for uPeriostin (0.831) and uPeriostin/Cr (0.768), and low for sPeriostin (0.656) and uCK-18 (0.615) for detecting renal injury. In conclusion, although serum and urine periostin and CK-18 did not display any relation to etiology or the type of CON treatment, uPeriostin seems to be a useful tool for detecting renal injury in children with CON, especially due to its strong negative correlation with DRF < 40%. |
format | Online Article Text |
id | pubmed-9115600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-91156002022-05-20 Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy Turczyn, Agnieszka Krzemień, Grażyna Górska, Elżbieta Demkow, Urszula Pańczyk-Tomaszewska, Małgorzata Cent Eur J Immunol Clinical Immunology Congenital obstructive nephropathy (CON) is one of the most common causes of chronic kidney disease in children. The aim of the study was to investigate serum and urine periostin and cytokeratin-18 (CK-18) in children with CON in relation to CON etiology, treatment, and kidney injury. We evaluated 81 children with CON secondary to ureteropelvic junction obstruction (UPJO), ureterovesical junction obstruction (UVJO), posterior urethral valves (PUV) and 60 controls. Neither biomarker demonstrated any relation to CON etiology. However, all patients showed significantly higher urine periostin (uPeriostin) and uPeriostin/Cr levels than the controls. Also, UVJO patients showed higher sCK-18 and uCK-18/Cr levels, and PUV patients showed higher uCK-18/Cr levels than the controls. Neither biomarker was found to have any relation to CON treatment. However, conservatively treated children and those before and after surgery showed significantly higher uPeriostin and uPeriostin/Cr levels than the controls. uPeriostin strongly correlated with differential renal function (DRF) < 40%. The ROC analysis demonstrated the best area under the curve (AUC) for uPeriostin (0.831) and uPeriostin/Cr (0.768), and low for sPeriostin (0.656) and uCK-18 (0.615) for detecting renal injury. In conclusion, although serum and urine periostin and CK-18 did not display any relation to etiology or the type of CON treatment, uPeriostin seems to be a useful tool for detecting renal injury in children with CON, especially due to its strong negative correlation with DRF < 40%. Termedia Publishing House 2022-05-10 2022 /pmc/articles/PMC9115600/ /pubmed/35600153 http://dx.doi.org/10.5114/ceji.2022.115687 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Clinical Immunology Turczyn, Agnieszka Krzemień, Grażyna Górska, Elżbieta Demkow, Urszula Pańczyk-Tomaszewska, Małgorzata Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy |
title | Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy |
title_full | Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy |
title_fullStr | Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy |
title_full_unstemmed | Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy |
title_short | Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy |
title_sort | serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy |
topic | Clinical Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115600/ https://www.ncbi.nlm.nih.gov/pubmed/35600153 http://dx.doi.org/10.5114/ceji.2022.115687 |
work_keys_str_mv | AT turczynagnieszka serumandurineperiostinandcytokeratin18inchildrenwithcongenitalobstructivenephropathy AT krzemiengrazyna serumandurineperiostinandcytokeratin18inchildrenwithcongenitalobstructivenephropathy AT gorskaelzbieta serumandurineperiostinandcytokeratin18inchildrenwithcongenitalobstructivenephropathy AT demkowurszula serumandurineperiostinandcytokeratin18inchildrenwithcongenitalobstructivenephropathy AT panczyktomaszewskamałgorzata serumandurineperiostinandcytokeratin18inchildrenwithcongenitalobstructivenephropathy |