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Influence of Nitrite on Formation of Tobacco-Specific Nitrosamines in Electronic Cigarette Liquids and Aerosols
[Image: see text] Tobacco-specific nitrosamine (TSNA) formation occurred during aerosol generation from select commercial cig-a-like e-cigarette products. To understand the drivers behind the potential formation of TSNAs in electronic cigarette (e-cigarette) aerosols and e-liquids, model e-liquid sy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115799/ https://www.ncbi.nlm.nih.gov/pubmed/35417138 http://dx.doi.org/10.1021/acs.chemrestox.1c00417 |
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author | Jin, Xiaohong C. Wagner, Karl A. Melvin, Matt S. Smith, Donna C. Pithawalla, Yezdi B. Gardner, William P. Avery, Karen C. Karles, Georgios D. |
author_facet | Jin, Xiaohong C. Wagner, Karl A. Melvin, Matt S. Smith, Donna C. Pithawalla, Yezdi B. Gardner, William P. Avery, Karen C. Karles, Georgios D. |
author_sort | Jin, Xiaohong C. |
collection | PubMed |
description | [Image: see text] Tobacco-specific nitrosamine (TSNA) formation occurred during aerosol generation from select commercial cig-a-like e-cigarette products. To understand the drivers behind the potential formation of TSNAs in electronic cigarette (e-cigarette) aerosols and e-liquids, model e-liquid systems were generated in the lab to demonstrate that nitrite can react with nicotine and minor alkaloids to form TSNAs in e-liquids. In the presence of nitrite and nicotine, TSNA levels in e-liquids increased over time and the process was accelerated by elevated temperature. Additionally, TSNAs formed during aerosol generation when nitrite was present in the corresponding e-liquids. The commercial e-cigarette products that showed higher levels and formation of TSNAs were observed to contain nitrite and minor alkaloid impurities in the corresponding e-liquids. This study provides valuable information about drivers for TSNA formation in e-liquids and e-cigarette aerosols that may be applied to the evaluation and quality assurance of e-cigarette products. |
format | Online Article Text |
id | pubmed-9115799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-91157992022-05-19 Influence of Nitrite on Formation of Tobacco-Specific Nitrosamines in Electronic Cigarette Liquids and Aerosols Jin, Xiaohong C. Wagner, Karl A. Melvin, Matt S. Smith, Donna C. Pithawalla, Yezdi B. Gardner, William P. Avery, Karen C. Karles, Georgios D. Chem Res Toxicol [Image: see text] Tobacco-specific nitrosamine (TSNA) formation occurred during aerosol generation from select commercial cig-a-like e-cigarette products. To understand the drivers behind the potential formation of TSNAs in electronic cigarette (e-cigarette) aerosols and e-liquids, model e-liquid systems were generated in the lab to demonstrate that nitrite can react with nicotine and minor alkaloids to form TSNAs in e-liquids. In the presence of nitrite and nicotine, TSNA levels in e-liquids increased over time and the process was accelerated by elevated temperature. Additionally, TSNAs formed during aerosol generation when nitrite was present in the corresponding e-liquids. The commercial e-cigarette products that showed higher levels and formation of TSNAs were observed to contain nitrite and minor alkaloid impurities in the corresponding e-liquids. This study provides valuable information about drivers for TSNA formation in e-liquids and e-cigarette aerosols that may be applied to the evaluation and quality assurance of e-cigarette products. American Chemical Society 2022-04-13 2022-05-16 /pmc/articles/PMC9115799/ /pubmed/35417138 http://dx.doi.org/10.1021/acs.chemrestox.1c00417 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Jin, Xiaohong C. Wagner, Karl A. Melvin, Matt S. Smith, Donna C. Pithawalla, Yezdi B. Gardner, William P. Avery, Karen C. Karles, Georgios D. Influence of Nitrite on Formation of Tobacco-Specific Nitrosamines in Electronic Cigarette Liquids and Aerosols |
title | Influence of
Nitrite on Formation of Tobacco-Specific
Nitrosamines in Electronic Cigarette Liquids and Aerosols |
title_full | Influence of
Nitrite on Formation of Tobacco-Specific
Nitrosamines in Electronic Cigarette Liquids and Aerosols |
title_fullStr | Influence of
Nitrite on Formation of Tobacco-Specific
Nitrosamines in Electronic Cigarette Liquids and Aerosols |
title_full_unstemmed | Influence of
Nitrite on Formation of Tobacco-Specific
Nitrosamines in Electronic Cigarette Liquids and Aerosols |
title_short | Influence of
Nitrite on Formation of Tobacco-Specific
Nitrosamines in Electronic Cigarette Liquids and Aerosols |
title_sort | influence of
nitrite on formation of tobacco-specific
nitrosamines in electronic cigarette liquids and aerosols |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115799/ https://www.ncbi.nlm.nih.gov/pubmed/35417138 http://dx.doi.org/10.1021/acs.chemrestox.1c00417 |
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