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Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer

PURPOSE: The RAD51 family of genes, including RAD51 and the five RAD51-like paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3), are known to be crucially associated with DNA damage repair pathway. Increasing evidence indicated that RAD51 family members were implicated in breast cancer tumorigenesis...

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Autores principales: Shi, Yaqin, Shen, Meng, Xu, Mengdan, Tao, Min, Chen, Kai, Zhu, Qingqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115836/
https://www.ncbi.nlm.nih.gov/pubmed/35601003
http://dx.doi.org/10.2147/IJGM.S350971
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author Shi, Yaqin
Shen, Meng
Xu, Mengdan
Tao, Min
Chen, Kai
Zhu, Qingqing
author_facet Shi, Yaqin
Shen, Meng
Xu, Mengdan
Tao, Min
Chen, Kai
Zhu, Qingqing
author_sort Shi, Yaqin
collection PubMed
description PURPOSE: The RAD51 family of genes, including RAD51 and the five RAD51-like paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3), are known to be crucially associated with DNA damage repair pathway. Increasing evidence indicated that RAD51 family members were implicated in breast cancer tumorigenesis. However, their biological roles and prognostic values in breast cancer have yet to be clarified. METHODS: In this study, by using the Oncomine and GEPIA databases, we explored the transcriptional levels of RAD51 family members in breast cancer. Besides, the associations between RAD51 family expression and clinical features were evaluated by using the UALCAN database and Kaplan–Meier (KM) Plotter. We also analyzed the mutations of the RAD51 family and differentially altered genes from the cBioPortal database. RESULTS: We found that RAD51 mRNA was significantly elevated in breast cancer samples than in normal tissues, while XRCC2 mRNA was downregulated. Besides, a remarkable correlation was detected between the expression of RAD51/RAD51B/XRCC2 genes and the breast cancer stage. Survival analysis utilizing the KM Plotter indicated that high RAD51 and XRCC3 mRNA was associated with a poor prognosis. Conversely, RFS data suggested that high levels of RAD51B/RAD51C/RAD51D/XRCC2 were associated with a favorable prognosis. Moreover, a high genetic variation rate of RAD51C (7%) was detected in breast cancer patients. CONCLUSION: Conclusively, we implied that RAD51 and XRCC3 might be potential targets for precision therapy in breast cancer and the RAD51B/RAD51C/RAD51D/XRCC2 genes have significant values for breast cancer prognosis.
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spelling pubmed-91158362022-05-19 Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer Shi, Yaqin Shen, Meng Xu, Mengdan Tao, Min Chen, Kai Zhu, Qingqing Int J Gen Med Original Research PURPOSE: The RAD51 family of genes, including RAD51 and the five RAD51-like paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3), are known to be crucially associated with DNA damage repair pathway. Increasing evidence indicated that RAD51 family members were implicated in breast cancer tumorigenesis. However, their biological roles and prognostic values in breast cancer have yet to be clarified. METHODS: In this study, by using the Oncomine and GEPIA databases, we explored the transcriptional levels of RAD51 family members in breast cancer. Besides, the associations between RAD51 family expression and clinical features were evaluated by using the UALCAN database and Kaplan–Meier (KM) Plotter. We also analyzed the mutations of the RAD51 family and differentially altered genes from the cBioPortal database. RESULTS: We found that RAD51 mRNA was significantly elevated in breast cancer samples than in normal tissues, while XRCC2 mRNA was downregulated. Besides, a remarkable correlation was detected between the expression of RAD51/RAD51B/XRCC2 genes and the breast cancer stage. Survival analysis utilizing the KM Plotter indicated that high RAD51 and XRCC3 mRNA was associated with a poor prognosis. Conversely, RFS data suggested that high levels of RAD51B/RAD51C/RAD51D/XRCC2 were associated with a favorable prognosis. Moreover, a high genetic variation rate of RAD51C (7%) was detected in breast cancer patients. CONCLUSION: Conclusively, we implied that RAD51 and XRCC3 might be potential targets for precision therapy in breast cancer and the RAD51B/RAD51C/RAD51D/XRCC2 genes have significant values for breast cancer prognosis. Dove 2022-05-13 /pmc/articles/PMC9115836/ /pubmed/35601003 http://dx.doi.org/10.2147/IJGM.S350971 Text en © 2022 Shi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Shi, Yaqin
Shen, Meng
Xu, Mengdan
Tao, Min
Chen, Kai
Zhu, Qingqing
Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
title Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
title_full Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
title_fullStr Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
title_full_unstemmed Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
title_short Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer
title_sort comprehensive analysis of the expression and prognosis for rad51 family in human breast cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115836/
https://www.ncbi.nlm.nih.gov/pubmed/35601003
http://dx.doi.org/10.2147/IJGM.S350971
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