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Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men

The identification and validation of biomarkers of food intake (BFIs) is a promising approach to develop more objective and complementary tools to the traditional dietary assessment methods. Concerning dairy, their evaluation in terms of intake is not simple, given the variety of existing foods, mak...

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Autores principales: Kim, Jinyoung, Blaser, Carola, Portmann, Reto, Badertscher, René, Marmonier, Corinne, Blot, Adeline, David, Jérémie, Stoffers, Helena, von Ah, Ueli, Bütikofer, Ueli, Vergères, Guy, Dardevet, Dominique, Polakof, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115859/
https://www.ncbi.nlm.nih.gov/pubmed/35600812
http://dx.doi.org/10.3389/fnut.2022.851931
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author Kim, Jinyoung
Blaser, Carola
Portmann, Reto
Badertscher, René
Marmonier, Corinne
Blot, Adeline
David, Jérémie
Stoffers, Helena
von Ah, Ueli
Bütikofer, Ueli
Vergères, Guy
Dardevet, Dominique
Polakof, Sergio
author_facet Kim, Jinyoung
Blaser, Carola
Portmann, Reto
Badertscher, René
Marmonier, Corinne
Blot, Adeline
David, Jérémie
Stoffers, Helena
von Ah, Ueli
Bütikofer, Ueli
Vergères, Guy
Dardevet, Dominique
Polakof, Sergio
author_sort Kim, Jinyoung
collection PubMed
description The identification and validation of biomarkers of food intake (BFIs) is a promising approach to develop more objective and complementary tools to the traditional dietary assessment methods. Concerning dairy, their evaluation in terms of intake is not simple, given the variety of existing foods, making it difficult to establish the association between specific dairy products consumption and the effects on human health, which is also dependent on the study population. Here, we aimed at identifying BFI of both milk (M) and yogurt (Y) in 14 healthy young (20–35 years) and 14 older (65–80 years). After a 3-week run-in period of dairy exclusion from the diet, the subjects acutely consumed 600 ml of M or Y. Metabolomics analyses were conducted on serum samples during the following 6 h (LC-MS and GC-MS). Several metabolites showing increased iAUC after milk or yogurt intake were considered as potential BFI, including lactose (M > Y, 2-fold), galactitol (M > Y, 1.5-fold), galactonate (M > Y, 1.2-fold), sphingosine-1-phosphate (M > Y from 2.1-fold), as well as an annotated disaccharide (Y > M, 3.6-fold). Delayed serum kinetics were also observed after Y compared to M intake lysine (+22 min), phenylalanine (+45 min), tyrosine (+30min), threonine (+38 min) 3-phenyllactic acid (+30 min), lactose (+30 min), galactitol (+45min) and galactonate (+30 min). The statistical significance of certain discriminant metabolites, such as sphingosine-1-phosphate and several free fatty acids, was not maintained in the older group. This could be related to the physiological modifications induced by aging, like dysregulated lipid metabolism, including delayed appearance of dodecanoic acid (+60 min) or altered postprandial appearance of myristic acid (+70% C(max)), 3-dehydroxycarnitine (−26% C(min)), decanoylcarnitine (−51% C(min)) and dodecanoylcarnitine (−40% C(min)). In conclusion, candidate BFI of milk or yogurt could be identified based on the modified postprandial response resulting from the fermentation of milk to yogurt. Moreover, population specificities (e.g., aging) should also be considered in future studies to obtain more accurate and specific BFI.
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spelling pubmed-91158592022-05-19 Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men Kim, Jinyoung Blaser, Carola Portmann, Reto Badertscher, René Marmonier, Corinne Blot, Adeline David, Jérémie Stoffers, Helena von Ah, Ueli Bütikofer, Ueli Vergères, Guy Dardevet, Dominique Polakof, Sergio Front Nutr Nutrition The identification and validation of biomarkers of food intake (BFIs) is a promising approach to develop more objective and complementary tools to the traditional dietary assessment methods. Concerning dairy, their evaluation in terms of intake is not simple, given the variety of existing foods, making it difficult to establish the association between specific dairy products consumption and the effects on human health, which is also dependent on the study population. Here, we aimed at identifying BFI of both milk (M) and yogurt (Y) in 14 healthy young (20–35 years) and 14 older (65–80 years). After a 3-week run-in period of dairy exclusion from the diet, the subjects acutely consumed 600 ml of M or Y. Metabolomics analyses were conducted on serum samples during the following 6 h (LC-MS and GC-MS). Several metabolites showing increased iAUC after milk or yogurt intake were considered as potential BFI, including lactose (M > Y, 2-fold), galactitol (M > Y, 1.5-fold), galactonate (M > Y, 1.2-fold), sphingosine-1-phosphate (M > Y from 2.1-fold), as well as an annotated disaccharide (Y > M, 3.6-fold). Delayed serum kinetics were also observed after Y compared to M intake lysine (+22 min), phenylalanine (+45 min), tyrosine (+30min), threonine (+38 min) 3-phenyllactic acid (+30 min), lactose (+30 min), galactitol (+45min) and galactonate (+30 min). The statistical significance of certain discriminant metabolites, such as sphingosine-1-phosphate and several free fatty acids, was not maintained in the older group. This could be related to the physiological modifications induced by aging, like dysregulated lipid metabolism, including delayed appearance of dodecanoic acid (+60 min) or altered postprandial appearance of myristic acid (+70% C(max)), 3-dehydroxycarnitine (−26% C(min)), decanoylcarnitine (−51% C(min)) and dodecanoylcarnitine (−40% C(min)). In conclusion, candidate BFI of milk or yogurt could be identified based on the modified postprandial response resulting from the fermentation of milk to yogurt. Moreover, population specificities (e.g., aging) should also be considered in future studies to obtain more accurate and specific BFI. Frontiers Media S.A. 2022-05-04 /pmc/articles/PMC9115859/ /pubmed/35600812 http://dx.doi.org/10.3389/fnut.2022.851931 Text en Copyright © 2022 Kim, Blaser, Portmann, Badertscher, Marmonier, Blot, David, Stoffers, von Ah, Bütikofer, Vergères, Dardevet and Polakof. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Kim, Jinyoung
Blaser, Carola
Portmann, Reto
Badertscher, René
Marmonier, Corinne
Blot, Adeline
David, Jérémie
Stoffers, Helena
von Ah, Ueli
Bütikofer, Ueli
Vergères, Guy
Dardevet, Dominique
Polakof, Sergio
Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men
title Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men
title_full Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men
title_fullStr Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men
title_full_unstemmed Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men
title_short Postprandial Responses on Serum Metabolome to Milk and Yogurt Intake in Young and Older Men
title_sort postprandial responses on serum metabolome to milk and yogurt intake in young and older men
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115859/
https://www.ncbi.nlm.nih.gov/pubmed/35600812
http://dx.doi.org/10.3389/fnut.2022.851931
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