Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial

BACKGROUND: Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. Tetanus toxin acts within the CNS, where there is limited penetration of peripherally administered antitoxin; thus, intrathecal antitoxin administration might impr...

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Detalles Bibliográficos
Autores principales: Van Hao, Nguyen, Loan, Huynh Thi, Yen, Lam Minh, Kestelyn, Evelyne, Hong, Duc Du, Thuy, Duong Bich, Nguyen, Nguyen Thanh, Duong, Ha Thi Hai, Thuy, Tran Thi Diem, Nhat, Phung Tran Huy, Khanh, Phan Nguyen Quoc, Dung, Nguyen Thi Phuong, Phu, Nguyen Hoan, Phong, Nguyen Thanh, Lieu, Pham Thi, Tuyen, Pham Thi, Hanh, Bui Thi Bich, Nghia, Ho Dang Trung, Oanh, Pham Kieu Nguyet, Tho, Phan Vinh, Tan Thanh, Tran, Turner, Hugo C, van Doorn, H Rogier, Van Tan, Le, Wyncoll, Duncan, Day, Nicholas PJ, Geskus, Ronald B, Thwaites, Guy E, Van Vinh Chau, Nguyen, Thwaites, C Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115864/
https://www.ncbi.nlm.nih.gov/pubmed/35561721
http://dx.doi.org/10.1016/S2214-109X(22)00117-6

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