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Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine

[Image: see text] The SARS-CoV-2 main protease (M(pro)) is a medicinal chemistry target for COVID-19 treatment. Given the clinical efficacy of β-lactams as inhibitors of bacterial nucleophilic enzymes, they are of interest as inhibitors of viral nucleophilic serine and cysteine proteases. We describ...

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Detalles Bibliográficos
Autores principales:	Malla, Tika R., Brewitz, Lennart, Muntean, Dorian-Gabriel, Aslam, Hiba, Owen, C. David, Salah, Eidarus, Tumber, Anthony, Lukacik, Petra, Strain-Damerell, Claire, Mikolajek, Halina, Walsh, Martin A., Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115881/ https://www.ncbi.nlm.nih.gov/pubmed/35549342 http://dx.doi.org/10.1021/acs.jmedchem.1c02214

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