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The Progress and Promise of RNA Medicine—An Arsenal of Targeted Treatments
[Image: see text] In the past decade, there has been a shift in research, clinical development, and commercial activity to exploit the many physiological roles of RNA for use in medicine. With the rapid success in the development of lipid–RNA nanoparticles for mRNA vaccines against COVID-19 and with...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115888/ https://www.ncbi.nlm.nih.gov/pubmed/35533054 http://dx.doi.org/10.1021/acs.jmedchem.2c00024 |
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author | Sasso, Janet M. Ambrose, Barbara J. B. Tenchov, Rumiana Datta, Ruchira S. Basel, Matthew T. DeLong, Robert K. Zhou, Qiongqiong Angela |
author_facet | Sasso, Janet M. Ambrose, Barbara J. B. Tenchov, Rumiana Datta, Ruchira S. Basel, Matthew T. DeLong, Robert K. Zhou, Qiongqiong Angela |
author_sort | Sasso, Janet M. |
collection | PubMed |
description | [Image: see text] In the past decade, there has been a shift in research, clinical development, and commercial activity to exploit the many physiological roles of RNA for use in medicine. With the rapid success in the development of lipid–RNA nanoparticles for mRNA vaccines against COVID-19 and with several approved RNA-based drugs, RNA has catapulted to the forefront of drug research. With diverse functions beyond the role of mRNA in producing antigens or therapeutic proteins, many classes of RNA serve regulatory roles in cells and tissues. These RNAs have potential as new therapeutics, with RNA itself serving as either a drug or a target. Here, based on the CAS Content Collection, we provide a landscape view of the current state and outline trends in RNA research in medicine across time, geography, therapeutic pipelines, chemical modifications, and delivery mechanisms. |
format | Online Article Text |
id | pubmed-9115888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-91158882022-05-18 The Progress and Promise of RNA Medicine—An Arsenal of Targeted Treatments Sasso, Janet M. Ambrose, Barbara J. B. Tenchov, Rumiana Datta, Ruchira S. Basel, Matthew T. DeLong, Robert K. Zhou, Qiongqiong Angela J Med Chem [Image: see text] In the past decade, there has been a shift in research, clinical development, and commercial activity to exploit the many physiological roles of RNA for use in medicine. With the rapid success in the development of lipid–RNA nanoparticles for mRNA vaccines against COVID-19 and with several approved RNA-based drugs, RNA has catapulted to the forefront of drug research. With diverse functions beyond the role of mRNA in producing antigens or therapeutic proteins, many classes of RNA serve regulatory roles in cells and tissues. These RNAs have potential as new therapeutics, with RNA itself serving as either a drug or a target. Here, based on the CAS Content Collection, we provide a landscape view of the current state and outline trends in RNA research in medicine across time, geography, therapeutic pipelines, chemical modifications, and delivery mechanisms. American Chemical Society 2022-05-09 2022-05-26 /pmc/articles/PMC9115888/ /pubmed/35533054 http://dx.doi.org/10.1021/acs.jmedchem.2c00024 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Sasso, Janet M. Ambrose, Barbara J. B. Tenchov, Rumiana Datta, Ruchira S. Basel, Matthew T. DeLong, Robert K. Zhou, Qiongqiong Angela The Progress and Promise of RNA Medicine—An Arsenal of Targeted Treatments |
title | The Progress and
Promise of RNA Medicine—An
Arsenal of Targeted Treatments |
title_full | The Progress and
Promise of RNA Medicine—An
Arsenal of Targeted Treatments |
title_fullStr | The Progress and
Promise of RNA Medicine—An
Arsenal of Targeted Treatments |
title_full_unstemmed | The Progress and
Promise of RNA Medicine—An
Arsenal of Targeted Treatments |
title_short | The Progress and
Promise of RNA Medicine—An
Arsenal of Targeted Treatments |
title_sort | progress and
promise of rna medicine—an
arsenal of targeted treatments |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115888/ https://www.ncbi.nlm.nih.gov/pubmed/35533054 http://dx.doi.org/10.1021/acs.jmedchem.2c00024 |
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