Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition

BACKGROUND: Activated Cdk5 regulates a number of processes during nervous system formation, including neuronal differentiation, growth cone stabilization, and axonal growth. Cdk5 phosphorylates its downstream substrates located in axonal growth cones, where the highly expressed c-Jun N-terminal kina...

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Detalles Bibliográficos
Autores principales: Im, Doo Soon, Joselin, Alvin, Svoboda, Devon, Takano, Tesuya, Rousseaux, Maxime W. C., Callaghan, Steve, Slack, Ruth S., Hisanaga, Shin-ichi, Davis, Roger J., Park, David S., Qu, Dianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115922/
https://www.ncbi.nlm.nih.gov/pubmed/35581583
http://dx.doi.org/10.1186/s12915-022-01312-4

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