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Human liver single nucleus and single cell RNA sequencing identify a hepatocellular carcinoma-associated cell-type affecting survival

BACKGROUND: Hepatocellular carcinoma (HCC) is a common primary liver cancer with poor overall survival. We hypothesized that there are HCC-associated cell-types that impact patient survival. METHODS: We combined liver single nucleus (snRNA-seq), single cell (scRNA-seq), and bulk RNA-sequencing (RNA-...

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Detalles Bibliográficos
Autores principales:	Alvarez, Marcus, Benhammou, Jihane N., Darci-Maher, Nicholas, French, Samuel W., Han, Steven B., Sinsheimer, Janet S., Agopian, Vatche G., Pisegna, Joseph R., Pajukanta, Päivi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115949/ https://www.ncbi.nlm.nih.gov/pubmed/35581624 http://dx.doi.org/10.1186/s13073-022-01055-5

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