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Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study
BACKGROUND: Parkinson’s disease (PD) is an increasingly common neurodegenerative disease in an aging society. Whether PD is associated with an increased suicide risk is unclear. Thus, we investigated the effect of new-onset PD on suicide. METHODS: Using the National Health Insurance Service Senior S...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115980/ https://www.ncbi.nlm.nih.gov/pubmed/35581575 http://dx.doi.org/10.1186/s12888-022-03990-4 |
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author | Jeong, Sung Hoon Hoon Kim, Seung Lee, Doo Woong Park, Eun-Cheol Jang, Suk-Yong |
author_facet | Jeong, Sung Hoon Hoon Kim, Seung Lee, Doo Woong Park, Eun-Cheol Jang, Suk-Yong |
author_sort | Jeong, Sung Hoon |
collection | PubMed |
description | BACKGROUND: Parkinson’s disease (PD) is an increasingly common neurodegenerative disease in an aging society. Whether PD is associated with an increased suicide risk is unclear. Thus, we investigated the effect of new-onset PD on suicide. METHODS: Using the National Health Insurance Service Senior Sample Cohort of South Korea, 17,143 incident PD patients and 17,143 risk set controls, matched by propensity score, were selected for follow-up. The incidence rate of suicide and 95% confidence interval (CI) were calculated based on a generalized linear model of the Poisson distribution. Effect sizes were expressed as hazard ratios (HRs) using the Cox proportional hazards model with a robust variance estimator that incorporated clustering within matched pairs. RESULTS: The incidence rate of suicide was 206.7 cases per 100,000 person-years (95% CI, 172.8–246.9) among the PD cohort. Compared to the matched controls, patients with PD were 2.64 times (HR, 2.64; 95% CI, 1.31–5.30) more likely to commit suicide during the first 180 days of follow-up and 2.47 times (HR, 2.47; 95% CI, 1.42–4.28) within the first 365 days of follow-up. During the entire follow-up period, patients with PD were 2.26 times more likely to commit suicide than were their matched controls (HR, 2.26; 95% CI, 1.67–3.06). CONCLUSION: Our findings indicated an increased risk of suicide in patients with new-onset PD, regardless of the period after diagnosis. Incorporating mental health care with social and environmental interventions into primary care and PD-specialized care can help reduce suicide risk in people with PD, improving suicide prevention, identification, and risk assessment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-022-03990-4. |
format | Online Article Text |
id | pubmed-9115980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91159802022-05-19 Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study Jeong, Sung Hoon Hoon Kim, Seung Lee, Doo Woong Park, Eun-Cheol Jang, Suk-Yong BMC Psychiatry Research BACKGROUND: Parkinson’s disease (PD) is an increasingly common neurodegenerative disease in an aging society. Whether PD is associated with an increased suicide risk is unclear. Thus, we investigated the effect of new-onset PD on suicide. METHODS: Using the National Health Insurance Service Senior Sample Cohort of South Korea, 17,143 incident PD patients and 17,143 risk set controls, matched by propensity score, were selected for follow-up. The incidence rate of suicide and 95% confidence interval (CI) were calculated based on a generalized linear model of the Poisson distribution. Effect sizes were expressed as hazard ratios (HRs) using the Cox proportional hazards model with a robust variance estimator that incorporated clustering within matched pairs. RESULTS: The incidence rate of suicide was 206.7 cases per 100,000 person-years (95% CI, 172.8–246.9) among the PD cohort. Compared to the matched controls, patients with PD were 2.64 times (HR, 2.64; 95% CI, 1.31–5.30) more likely to commit suicide during the first 180 days of follow-up and 2.47 times (HR, 2.47; 95% CI, 1.42–4.28) within the first 365 days of follow-up. During the entire follow-up period, patients with PD were 2.26 times more likely to commit suicide than were their matched controls (HR, 2.26; 95% CI, 1.67–3.06). CONCLUSION: Our findings indicated an increased risk of suicide in patients with new-onset PD, regardless of the period after diagnosis. Incorporating mental health care with social and environmental interventions into primary care and PD-specialized care can help reduce suicide risk in people with PD, improving suicide prevention, identification, and risk assessment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-022-03990-4. BioMed Central 2022-05-17 /pmc/articles/PMC9115980/ /pubmed/35581575 http://dx.doi.org/10.1186/s12888-022-03990-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Jeong, Sung Hoon Hoon Kim, Seung Lee, Doo Woong Park, Eun-Cheol Jang, Suk-Yong Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study |
title | Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study |
title_full | Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study |
title_fullStr | Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study |
title_full_unstemmed | Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study |
title_short | Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study |
title_sort | association between new-onset parkinson’s disease and suicide risk in south korea: a nationwide cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115980/ https://www.ncbi.nlm.nih.gov/pubmed/35581575 http://dx.doi.org/10.1186/s12888-022-03990-4 |
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