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Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France
BACKGROUND: The mortality rate associated with coronavirus disease 2019 (COVID-19) is high among haemodialyzed patients. We sought to describe the serological status of haemodialysis patients having received up to three doses of BNT162b2 mRNA vaccine, and to identify factors associated with a poor h...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116059/ https://www.ncbi.nlm.nih.gov/pubmed/35585512 http://dx.doi.org/10.1186/s12882-022-02751-5 |
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author | Verdier, Jean-François Boyer, Sonia Chalmin, Florence Jeribi, Ahmed Egasse, Caroline Maggi, Marie France Auvray, Philippe Yalaoui, Tarik |
author_facet | Verdier, Jean-François Boyer, Sonia Chalmin, Florence Jeribi, Ahmed Egasse, Caroline Maggi, Marie France Auvray, Philippe Yalaoui, Tarik |
author_sort | Verdier, Jean-François |
collection | PubMed |
description | BACKGROUND: The mortality rate associated with coronavirus disease 2019 (COVID-19) is high among haemodialyzed patients. We sought to describe the serological status of haemodialysis patients having received up to three doses of BNT162b2 mRNA vaccine, and to identify factors associated with a poor humoral response. METHODS: We performed a retrospective, observational study of patients attending a dialysis centre in Antibes, France. One or two of each patient’s monthly venous blood samples were assayed for anti–spike (S1) immunoglobulin G (IgG). RESULTS: We included 142 patients, of whom 124 remained COVID-19-negative throughout the study. Among these COVID-19-negative patients, the humoral immune response rate (defined as an anti-S1 IgG titre ≥1.2 U/ml) was 82.9% after two injections and 95.8% after three injections, and the median [interquartile range] titre increased significantly from 7.09 [2.21; 19.94] U/ml with two injections to 93.26 [34.25; 176.06] U/ml with three. Among patients with two injections, the mean body mass index and serum albumin levels were significantly higher in responders than in non-responders (26.5 kg/m(2) vs. 23.2 kg/m(2), p = 0.0392; and 41.9 g/l vs. 39.0 g/l, p = 0.0042, respectively). For the study population as a whole at the end of the study, a history of COVID-19, at least two vaccine doses, and being on the French national waiting list for kidney transplantation were the only factors independently associated with the anti-S1 IgG titre. CONCLUSIONS: Dialysis patients vaccinated with two doses of BNT162b2 might not be sufficiently protected against SARS-CoV-2 and so should receive a third (booster) dose. TRIAL REGISTRATION: The present retrospective study of clinical practice was not interventional and so was not registered. |
format | Online Article Text |
id | pubmed-9116059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91160592022-05-18 Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France Verdier, Jean-François Boyer, Sonia Chalmin, Florence Jeribi, Ahmed Egasse, Caroline Maggi, Marie France Auvray, Philippe Yalaoui, Tarik BMC Nephrol Research BACKGROUND: The mortality rate associated with coronavirus disease 2019 (COVID-19) is high among haemodialyzed patients. We sought to describe the serological status of haemodialysis patients having received up to three doses of BNT162b2 mRNA vaccine, and to identify factors associated with a poor humoral response. METHODS: We performed a retrospective, observational study of patients attending a dialysis centre in Antibes, France. One or two of each patient’s monthly venous blood samples were assayed for anti–spike (S1) immunoglobulin G (IgG). RESULTS: We included 142 patients, of whom 124 remained COVID-19-negative throughout the study. Among these COVID-19-negative patients, the humoral immune response rate (defined as an anti-S1 IgG titre ≥1.2 U/ml) was 82.9% after two injections and 95.8% after three injections, and the median [interquartile range] titre increased significantly from 7.09 [2.21; 19.94] U/ml with two injections to 93.26 [34.25; 176.06] U/ml with three. Among patients with two injections, the mean body mass index and serum albumin levels were significantly higher in responders than in non-responders (26.5 kg/m(2) vs. 23.2 kg/m(2), p = 0.0392; and 41.9 g/l vs. 39.0 g/l, p = 0.0042, respectively). For the study population as a whole at the end of the study, a history of COVID-19, at least two vaccine doses, and being on the French national waiting list for kidney transplantation were the only factors independently associated with the anti-S1 IgG titre. CONCLUSIONS: Dialysis patients vaccinated with two doses of BNT162b2 might not be sufficiently protected against SARS-CoV-2 and so should receive a third (booster) dose. TRIAL REGISTRATION: The present retrospective study of clinical practice was not interventional and so was not registered. BioMed Central 2022-05-18 /pmc/articles/PMC9116059/ /pubmed/35585512 http://dx.doi.org/10.1186/s12882-022-02751-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Verdier, Jean-François Boyer, Sonia Chalmin, Florence Jeribi, Ahmed Egasse, Caroline Maggi, Marie France Auvray, Philippe Yalaoui, Tarik Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France |
title | Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France |
title_full | Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France |
title_fullStr | Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France |
title_full_unstemmed | Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France |
title_short | Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France |
title_sort | response to three doses of the pfizer/biontech bnt162b2 covid-19 vaccine: a retrospective study of a cohort of haemodialysis patients in france |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116059/ https://www.ncbi.nlm.nih.gov/pubmed/35585512 http://dx.doi.org/10.1186/s12882-022-02751-5 |
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