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Plasma cell IgG4 positivity in orbital biopsies of non-IgG4-related conditions

The IgG4-related disease (IgG4-RD) is a systemic condition defined as a fibro-inflammatory disorder, characterized by the occurrence of tumor-like lesions in multiple organs including the eye adnexa. The main diagnostic criterion is based on histopathological findings, especially on the IgG4(+)/IgG(...

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Autores principales: Cruz, Antonio A.V., Camacho, Maria A.B., Cunha, Barbara S., Alkatan, Hind M., Xavier, Naiara F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116107/
https://www.ncbi.nlm.nih.gov/pubmed/35601849
http://dx.doi.org/10.4103/SJOPT.SJOPT_91_21
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author Cruz, Antonio A.V.
Camacho, Maria A.B.
Cunha, Barbara S.
Alkatan, Hind M.
Xavier, Naiara F.
author_facet Cruz, Antonio A.V.
Camacho, Maria A.B.
Cunha, Barbara S.
Alkatan, Hind M.
Xavier, Naiara F.
author_sort Cruz, Antonio A.V.
collection PubMed
description The IgG4-related disease (IgG4-RD) is a systemic condition defined as a fibro-inflammatory disorder, characterized by the occurrence of tumor-like lesions in multiple organs including the eye adnexa. The main diagnostic criterion is based on histopathological findings, especially on the IgG4(+)/IgG(+) plasma cell ratio. In this article, we reviewed the literature of non-IgG4-RD orbital conditions with IgG4 positivity. There were 20 reports of inflammatory non-IgG4-RD orbital lesions and 14 reports of orbital lymphoid proliferations with significant IgG4 positivity. The role of plasma cells IgG4 in the pathogenesis of non-IgG4-RD is not clear. Considering the large spectrum of diseases caused by a variety of different etiopathogenic mechanisms, we think that the common denominator of IgG4(+) in these conditions might be related to the peculiar properties of down regulation of immune response of the IgG4 and not to a specific link to IgG4-RD.
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spelling pubmed-91161072022-05-19 Plasma cell IgG4 positivity in orbital biopsies of non-IgG4-related conditions Cruz, Antonio A.V. Camacho, Maria A.B. Cunha, Barbara S. Alkatan, Hind M. Xavier, Naiara F. Saudi J Ophthalmol Oculoplasty and Ophthalmic Pathology Update The IgG4-related disease (IgG4-RD) is a systemic condition defined as a fibro-inflammatory disorder, characterized by the occurrence of tumor-like lesions in multiple organs including the eye adnexa. The main diagnostic criterion is based on histopathological findings, especially on the IgG4(+)/IgG(+) plasma cell ratio. In this article, we reviewed the literature of non-IgG4-RD orbital conditions with IgG4 positivity. There were 20 reports of inflammatory non-IgG4-RD orbital lesions and 14 reports of orbital lymphoid proliferations with significant IgG4 positivity. The role of plasma cells IgG4 in the pathogenesis of non-IgG4-RD is not clear. Considering the large spectrum of diseases caused by a variety of different etiopathogenic mechanisms, we think that the common denominator of IgG4(+) in these conditions might be related to the peculiar properties of down regulation of immune response of the IgG4 and not to a specific link to IgG4-RD. Wolters Kluwer - Medknow 2021-11-17 /pmc/articles/PMC9116107/ /pubmed/35601849 http://dx.doi.org/10.4103/SJOPT.SJOPT_91_21 Text en Copyright: © 2021 Saudi Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Oculoplasty and Ophthalmic Pathology Update
Cruz, Antonio A.V.
Camacho, Maria A.B.
Cunha, Barbara S.
Alkatan, Hind M.
Xavier, Naiara F.
Plasma cell IgG4 positivity in orbital biopsies of non-IgG4-related conditions
title Plasma cell IgG4 positivity in orbital biopsies of non-IgG4-related conditions
title_full Plasma cell IgG4 positivity in orbital biopsies of non-IgG4-related conditions
title_fullStr Plasma cell IgG4 positivity in orbital biopsies of non-IgG4-related conditions
title_full_unstemmed Plasma cell IgG4 positivity in orbital biopsies of non-IgG4-related conditions
title_short Plasma cell IgG4 positivity in orbital biopsies of non-IgG4-related conditions
title_sort plasma cell igg4 positivity in orbital biopsies of non-igg4-related conditions
topic Oculoplasty and Ophthalmic Pathology Update
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116107/
https://www.ncbi.nlm.nih.gov/pubmed/35601849
http://dx.doi.org/10.4103/SJOPT.SJOPT_91_21
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