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The Yin and Yang of IL-17 in Systemic Sclerosis

IL-17 (IL-17A) is a pro-inflammatory cytokine produced by a sub-set of T helper cells termed Th17 cells primarily in response to cytokines like TGF-β and IL-23 and play an important role in host defense. IL-17 signals via the IL-17RA/RC heterodimer and the adaptor protein Act1 to activate both canon...

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Autores principales: Wei, Lanxuan, Abraham, David, Ong, Voon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116143/
https://www.ncbi.nlm.nih.gov/pubmed/35603223
http://dx.doi.org/10.3389/fimmu.2022.885609
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author Wei, Lanxuan
Abraham, David
Ong, Voon
author_facet Wei, Lanxuan
Abraham, David
Ong, Voon
author_sort Wei, Lanxuan
collection PubMed
description IL-17 (IL-17A) is a pro-inflammatory cytokine produced by a sub-set of T helper cells termed Th17 cells primarily in response to cytokines like TGF-β and IL-23 and play an important role in host defense. IL-17 signals via the IL-17RA/RC heterodimer and the adaptor protein Act1 to activate both canonical and non-canonical pathways inducing transcriptional activation and stabilization of mRNAs. IL-17 appears to act not directly on immune cells but stimulates stromal cells such as endothelial and epithelial cells and fibroblasts to secrete other immunomodulatory factors. Fibroblast activated by IL-17 can support the growth and differentiation of immune cells. Studies have begun to uncover a dual role for IL-17; on one hand enhancing immune reactions and promoting inflammatory diseases and on the other decreasing responses and immune activity in established disease settings. The balance of double-edged sword effect of IL-17 and autoimmunity is illustrated in a variety of human diseases and experimental models of diseases. Specifically, the emerging interest in autoimmunity in systemic sclerosis (Scleroderma, SSc) has led to potential role of IL-17A as a target therapy in this disease.
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spelling pubmed-91161432022-05-19 The Yin and Yang of IL-17 in Systemic Sclerosis Wei, Lanxuan Abraham, David Ong, Voon Front Immunol Immunology IL-17 (IL-17A) is a pro-inflammatory cytokine produced by a sub-set of T helper cells termed Th17 cells primarily in response to cytokines like TGF-β and IL-23 and play an important role in host defense. IL-17 signals via the IL-17RA/RC heterodimer and the adaptor protein Act1 to activate both canonical and non-canonical pathways inducing transcriptional activation and stabilization of mRNAs. IL-17 appears to act not directly on immune cells but stimulates stromal cells such as endothelial and epithelial cells and fibroblasts to secrete other immunomodulatory factors. Fibroblast activated by IL-17 can support the growth and differentiation of immune cells. Studies have begun to uncover a dual role for IL-17; on one hand enhancing immune reactions and promoting inflammatory diseases and on the other decreasing responses and immune activity in established disease settings. The balance of double-edged sword effect of IL-17 and autoimmunity is illustrated in a variety of human diseases and experimental models of diseases. Specifically, the emerging interest in autoimmunity in systemic sclerosis (Scleroderma, SSc) has led to potential role of IL-17A as a target therapy in this disease. Frontiers Media S.A. 2022-05-04 /pmc/articles/PMC9116143/ /pubmed/35603223 http://dx.doi.org/10.3389/fimmu.2022.885609 Text en Copyright © 2022 Wei, Abraham and Ong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wei, Lanxuan
Abraham, David
Ong, Voon
The Yin and Yang of IL-17 in Systemic Sclerosis
title The Yin and Yang of IL-17 in Systemic Sclerosis
title_full The Yin and Yang of IL-17 in Systemic Sclerosis
title_fullStr The Yin and Yang of IL-17 in Systemic Sclerosis
title_full_unstemmed The Yin and Yang of IL-17 in Systemic Sclerosis
title_short The Yin and Yang of IL-17 in Systemic Sclerosis
title_sort yin and yang of il-17 in systemic sclerosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116143/
https://www.ncbi.nlm.nih.gov/pubmed/35603223
http://dx.doi.org/10.3389/fimmu.2022.885609
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